The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022
Tuft Cells Are Present in Submandibular Glands Across Species.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Tavares Dos Santos Harim, Nam Kihoon, Maslow Frank M, Small Travis, Galloway Tabitha L I, Dooley Laura M, Tassone Patrick T, Zitsch Robert P, Weisman Gary A, Baker Olga J
Аннотация
Tuft cells are bottle-shaped, microvilli-projecting chemosensory cells located in the lining of a variety of epithelial tissues and, following their identification approximately 60 years ago, have been linked to immune system function in a variety of epithelia. Until recently, Tuft cells had not been convincingly demonstrated to be present in salivary glands with their detection by transmission electron microscopy only shown in a handful of earlier studies using rat salivary glands, and no follow-up work has been conducted to verify their presence in salivary glands of other species. Here, we demonstrate that Tuft cells are present in the submandibular glands of various species (i.e., mouse, pig and human) using transmission electron microscopy and confocal immunofluorescent analysis for the POU class 2 homeobox 3 (POU2F3), which is considered to be a master regulator of Tuft cell identity.