CT-guided biopsy in two cases of retroperitoneal fibrosis.

Diffuse retroperitoneal fibrosis (RPF) is a rare inflammatory process. We report on two known cases of RPF, without evidence of involvement of the urinary tract or of the venous system. A computed tomography (CT)-guided biopsy was performed in each case, and the histological findings eliminated other pathological processes, particularly those of malignant origin. In both cases, a therapy with cortisone was instituted, and a follow-up with CT at 6 months has demonstrated a regression of the pathology of more than 50%.