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DOI 10.1038/s41588-021-00921-z

Медицинская библиотека · Nature genetics · 2021

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease.

Wightman Douglas P, Jansen Iris E, Savage Jeanne E, Shadrin Alexey A, Bahrami Shahram, Holland Dominic, Rongve Arvid, Børte Sigrid, Winsvold Bendik S, Drange Ole Kristian, Martinsen Amy E, Skogholt Anne Heidi, Willer Cristen, Bråthen Geir, Bosnes Ingunn, Nielsen Jonas Bille, Fritsche Lars G, Thomas Laurent F, Pedersen Linda M, Gabrielsen Maiken E, Johnsen Marianne Bakke, Meisingset Tore Wergeland, Zhou Wei, Proitsi Petroula, Hodges Angela, Dobson Richard, Velayudhan Latha, Heilbron Karl, Auton Adam, 23andMe Research Team, Sealock Julia M, Davis Lea K, Pedersen Nancy L, Reynolds Chandra A, Karlsson Ida K, Magnusson Sigurdur, Stefansson Hreinn, Thordardottir Steinunn, Jonsson Palmi V, Snaedal Jon, Zettergren Anna, Skoog Ingmar, Kern Silke, Waern Margda, Zetterberg Henrik, Blennow Kaj, Stordal Eystein, Hveem Kristian, Zwart John-Anker, Athanasiu Lavinia, Selnes Per, Saltvedt Ingvild, Sando Sigrid B, Ulstein Ingun, Djurovic Srdjan, Fladby Tormod, Aarsland Dag, Selbæk Geir, Ripke Stephan, Stefansson Kari, Andreassen Ole A, Posthuma Danielle

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts for 50-70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer's disease have been identified. Here we show that increased sample sizes allowed identification of seven previously unidentified genetic loci contributing to Alzheimer's disease. This study highlights microglia, immune cells and protein catabolism as relevant to late-onset Alzheimer's disease, while identifying and prioritizing previously unidentified genes of potential interest. We anticipate that these results can be included in larger meta-analyses of Alzheimer's disease to identify further genetic variants that contribute to Alzheimer's pathology.

Для цитирования: Wightman Douglas P, Jansen Iris E, Savage Jeanne E, Shadrin Alexey A, Bahrami Shahram, Holland Dominic, Rongve Arvid, Børte Sigrid, Winsvold Bendik S, Drange Ole Kristian, Martinsen Amy E, Skogholt Anne Heidi, Willer Cristen, Bråthen Geir, Bosnes Ingunn, Nielsen Jonas Bille, Fritsche Lars G, Thomas Laurent F, Pedersen Linda M, Gabrielsen Maiken E, Johnsen Marianne Bakke, Meisingset Tore Wergeland, Zhou Wei, Proitsi Petroula, Hodges Angela, Dobson Richard, Velayudhan Latha, Heilbron Karl, Auton Adam, 23andMe Research Team, Sealock Julia M, Davis Lea K, Pedersen Nancy L, Reynolds Chandra A, Karlsson Ida K, Magnusson Sigurdur, Stefansson Hreinn, Thordardottir Steinunn, Jonsson Palmi V, Snaedal Jon, Zettergren Anna, Skoog Ingmar, Kern Silke, Waern Margda, Zetterberg Henrik, Blennow Kaj, Stordal Eystein, Hveem Kristian, Zwart John-Anker, Athanasiu Lavinia, Selnes Per, Saltvedt Ingvild, Sando Sigrid B, Ulstein Ingun, Djurovic Srdjan, Fladby Tormod, Aarsland Dag, Selbæk Geir, Ripke Stephan, Stefansson Kari, Andreassen Ole A, Posthuma Danielle. A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease.. Nature genetics. 2021. DOI: 10.1038/s41588-021-00921-z.

Предметные рубрики MeSH

Alzheimer DiseaseGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMicrogliaMultifactorial InheritancePolymorphism, Single NucleotideProteinsProteolysisSample Size
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