MetaRoundWorm: A Virtual Reality Escape Room Game for Learning the Lifecycle and Immune Response to Parasitic Infections.

Promoting public health is challenging owing to its abstract nature, and individuals may be apprehensive about confronting it. Recently, there has been an increasing interest in using the metaverse and gamification as novel educational techniques to improve learning experiences related to the immune system. Thus, we present MetaRoundWorm, an immersive virtual reality (VR) escape room game designed to enhance the understanding of parasitic infections and host immune responses through interactive, gamified learning. The application simulates the lifecycle of Ascaris lumbricoides and corresponding immunological mechanisms across anatomically accurate environments within the human body. Integrating serious game mechanics with embodied learning principles, MetaRoundWorm offers players a task-driven experience combining exploration, puzzle-solving, and immune system simulation. To evaluate the educational efficacy and user engagement, we conducted a controlled study comparing MetaRoundWorm against a traditional approach, i.e., interactive slides. Results indicate that MetaRoundWorm significantly improves immediate learning outcomes, cognitive engagement, and emotional experience, while maintaining knowledge retention over time. Our findings suggest that immersive VR gamification holds promise as an effective pedagogical tool for communicating complex biomedical concepts and advancing digital health education.