Head & neck · 2010
Correlation between lymphatic vessel density and regional metastasis in squamous cell carcinoma of the tongue.
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Chung Man Ki, Min Jin-Young, So Yoon Kyoung, Ko Young-Hyeh, Jeong Han-Sin, Son Young-Ik, Baek Chung-Hwan
Аннотация
BACKGROUND: The aim of this study was to investigate the correlation between lymphatic vessel density in squamous cell carcinoma of the tongue and regional metastasis.
METHODS: Intratumoral and peritumoral lymphatic densities (ILDs and PLDs, respectively) were determined by immunohistochemical staining of lymphatic endothelial cells with podoplanin in 62 patients surgically treated for tongue cancer. Clinicopathological variables were quantified, and their correlations with regional metastasis were assessed.
RESULTS: The rate of regional metastasis was significantly higher in patients with high ILD than that in those with low ILD (21/33, 63.6% vs 8/29, 27.5%; p = .006). Perineural invasion and lymphovascular invasion were also significantly correlated with regional metastasis. By multivariate analyses, ILD was the only variable identified to be significantly correlated with regional metastasis (p = .009). On the other hand, PLD showed no correlation with regional metastasis.
CONCLUSIONS: ILD showed a strong correlation with regional metastasis in patients with squamous cell carcinoma of the tongue.
METHODS: Intratumoral and peritumoral lymphatic densities (ILDs and PLDs, respectively) were determined by immunohistochemical staining of lymphatic endothelial cells with podoplanin in 62 patients surgically treated for tongue cancer. Clinicopathological variables were quantified, and their correlations with regional metastasis were assessed.
RESULTS: The rate of regional metastasis was significantly higher in patients with high ILD than that in those with low ILD (21/33, 63.6% vs 8/29, 27.5%; p = .006). Perineural invasion and lymphovascular invasion were also significantly correlated with regional metastasis. By multivariate analyses, ILD was the only variable identified to be significantly correlated with regional metastasis (p = .009). On the other hand, PLD showed no correlation with regional metastasis.
CONCLUSIONS: ILD showed a strong correlation with regional metastasis in patients with squamous cell carcinoma of the tongue.
Предметные рубрики MeSH
AdultAgedBiopsy, NeedleCarcinoma, Squamous CellChi-Square DistributionCohort StudiesFemaleHumansImmunohistochemistryLymphatic MetastasisLymphatic VesselsMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingProbabilityPrognosisRetrospective StudiesRisk AssessmentSensitivity and SpecificityStatistics, NonparametricSurvival AnalysisTongue NeoplasmsYoung Adult