Journal of the American Academy of Dermatology · 1994
Antipsoriatic effect of fumaric acid derivatives. Results of a multicenter double-blind study in 100 patients.
Клиническое исследованиеСтатьяМногоцентровое исследованиеРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Altmeyer P J, Matthes U, Pawlak F, Hoffmann K, Frosch P J, Ruppert P, Wassilew S W, Horn T, Kreysel H W, Lutz G
Аннотация
BACKGROUND: Psoriasis vulgaris may benefit from treatment with fumaric acid and/or its derivatives; however, because different preparations have been used, results have been contradictory and difficult to interpret.
OBJECTIVE: The purpose of this clinical trial was to evaluate the therapeutic value of fumaric acid derivatives.
METHODS: A randomized double-blind study was carried out in patients with psoriasis, comparing a well-characterized formulation of fumaric acid derivatives with placebo.
RESULTS: The results indicated statistically significant superiority of the fumaric acid derivatives over placebo. Adverse events (flush, gastrointestinal disturbances) were initially relatively frequent, but decreased thereafter.
CONCLUSION: Fumaric acid derivatives were found to be effective and safe in the treatment of psoriasis.
OBJECTIVE: The purpose of this clinical trial was to evaluate the therapeutic value of fumaric acid derivatives.
METHODS: A randomized double-blind study was carried out in patients with psoriasis, comparing a well-characterized formulation of fumaric acid derivatives with placebo.
RESULTS: The results indicated statistically significant superiority of the fumaric acid derivatives over placebo. Adverse events (flush, gastrointestinal disturbances) were initially relatively frequent, but decreased thereafter.
CONCLUSION: Fumaric acid derivatives were found to be effective and safe in the treatment of psoriasis.