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DOI 10.1038/s44161-024-00462-8

Медицинская библиотека · Nature cardiovascular research · 2024

Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion.

Tuz Ali A, Ghosh Susmita, Karsch Laura, Ttoouli Dimitris, Sata Sai P, Ulusoy Özgür, Kraus Andreas, Hoerenbaum Nils, Wolf Jan-Niklas, Lohmann Sabrina, Zwirnlein Franziska, Kaygusuz Viola, Lakovic Vivian, Tummes Hannah-Lea, Beer Alexander, Gallert Markus, Thiebes Stephanie, Qefalia Altea, Cibir Zülal, Antler Medina, Korste Sebastian, Haj Yehia Elias, Michel Lars, Rassaf Tienush, Kaltwasser Britta, Abdelrahman Hossam, Mohamud Yusuf Ayan, Wang Chen, Yin Dongpei, Haeusler Lars, Lueong Smiths, Richter Mathis, Engel Daniel R, Stenzel Martin, Soehnlein Oliver, Frank Benedikt, Solo-Nomenjanahary Mialitiana, Ho-Tin-Noé Benoît, Siveke Jens T, Totzeck Matthias, Hoffmann Daniel, Grüneboom Anika, Hagemann Nina, Hasenberg Anja, Desilles Jean-Philippe, Mazighi Mikael, Sickmann Albert, Chen Jianxu, Hermann Dirk M, Gunzer Matthias, Singh Vikramjeet

СтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

Post-injury dysfunction of humoral immunity accounts for infections and poor outcomes in cardiovascular diseases. Among immunoglobulins (Ig), IgA, the most abundant mucosal antibody, is produced by plasma B cells in intestinal Peyer's patches (PP) and lamina propria. Here we show that patients with stroke and myocardial ischemia (MI) had strongly reduced IgA blood levels. This was phenocopied in experimental mouse models where decreased plasma and fecal IgA were accompanied by rapid loss of IgA-producing plasma cells in PP and lamina propria. Reduced plasma IgG was detectable in patients and experimental mice 3-10 d after injury. Stroke/MI triggered the release of neutrophil extracellular traps (NETs). Depletion of neutrophils, NET degradation or blockade of NET release inhibited the loss of IgA+ cells and circulating IgA in experimental stroke and MI and in patients with stroke. Our results unveil how tissue-injury-triggered systemic NET release disrupts physiological Ig secretion and how this can be inhibited in patients.

Для цитирования: Tuz Ali A, Ghosh Susmita, Karsch Laura, Ttoouli Dimitris, Sata Sai P, Ulusoy Özgür, Kraus Andreas, Hoerenbaum Nils, Wolf Jan-Niklas, Lohmann Sabrina, Zwirnlein Franziska, Kaygusuz Viola, Lakovic Vivian, Tummes Hannah-Lea, Beer Alexander, Gallert Markus, Thiebes Stephanie, Qefalia Altea, Cibir Zülal, Antler Medina, Korste Sebastian, Haj Yehia Elias, Michel Lars, Rassaf Tienush, Kaltwasser Britta, Abdelrahman Hossam, Mohamud Yusuf Ayan, Wang Chen, Yin Dongpei, Haeusler Lars, Lueong Smiths, Richter Mathis, Engel Daniel R, Stenzel Martin, Soehnlein Oliver, Frank Benedikt, Solo-Nomenjanahary Mialitiana, Ho-Tin-Noé Benoît, Siveke Jens T, Totzeck Matthias, Hoffmann Daniel, Grüneboom Anika, Hagemann Nina, Hasenberg Anja, Desilles Jean-Philippe, Mazighi Mikael, Sickmann Albert, Chen Jianxu, Hermann Dirk M, Gunzer Matthias, Singh Vikramjeet. Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion.. Nature cardiovascular research. 2024. DOI: 10.1038/s44161-024-00462-8.

Предметные рубрики MeSH

Extracellular TrapsHumansAnimalsMyocardial InfarctionMaleNeutrophilsFemaleDisease Models, AnimalMice, Inbred C57BLStrokePeyer's PatchesImmunoglobulin AAgedMiddle AgedImmunoglobulin GImmunity, HumoralCase-Control StudiesMicePlasma Cells
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