Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
Non-verbal dichotic listening: A new cognitive hearing test for dementia.
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Hardy Chris J D, Levett Benjamin A, Jiang Jessica, Core Lucy B, Froud Sophie, Bishop Lauren, Lim Dicky, Durrani Faiza, Volkmer Anna, Koohi Nehzat, Bamiou Doris-Eva, Marshall Charles R, Warren Jason D
Аннотация
INTRODUCTION: Central hearing difficulties are a feature of Alzheimer's disease (AD) but not well captured by standard speech perception tests.
METHODS: We developed a non-verbal dichotic listening test (NVDLT) based on everyday sounds, and compared this with a standard verbal dichotic listening test (VDLT) in 36 people with primary progressive aphasia (PPA), 18 with typical AD (tAD), 6 with right temporal-variant frontotemporal dementia (rtvFTD), and 29 cognitively-healthy controls. Daily-life hearing function was assessed using the modified Amsterdam Inventory for Auditory Disability and Handicap (mAIAD).
RESULTS: On NVDLT, all dementia groups except rtvFTD performed worse than controls; tAD, logopenic-variant PPA and nonfluent/agrammatic-variant PPA performed worse than rtvFTD. NVDLT performance predicted atrophy in the retrosplenial cortex and hippocampus. NVDLT score discriminated tAD patients from controls with near-perfect accuracy (area under the curve [AUC] = 0.99) and predicted daily-life hearing function (r = 0.57).
DISCUSSION: NVDLT performance indexes daily-life hearing function and may aid dementia diagnosis, potentially in culturally-diverse populations.
METHODS: We developed a non-verbal dichotic listening test (NVDLT) based on everyday sounds, and compared this with a standard verbal dichotic listening test (VDLT) in 36 people with primary progressive aphasia (PPA), 18 with typical AD (tAD), 6 with right temporal-variant frontotemporal dementia (rtvFTD), and 29 cognitively-healthy controls. Daily-life hearing function was assessed using the modified Amsterdam Inventory for Auditory Disability and Handicap (mAIAD).
RESULTS: On NVDLT, all dementia groups except rtvFTD performed worse than controls; tAD, logopenic-variant PPA and nonfluent/agrammatic-variant PPA performed worse than rtvFTD. NVDLT performance predicted atrophy in the retrosplenial cortex and hippocampus. NVDLT score discriminated tAD patients from controls with near-perfect accuracy (area under the curve [AUC] = 0.99) and predicted daily-life hearing function (r = 0.57).
DISCUSSION: NVDLT performance indexes daily-life hearing function and may aid dementia diagnosis, potentially in culturally-diverse populations.