Transactions of the Royal Society of Tropical Medicine and Hygiene · 2026
The activity of combinations of currently used antigiardial drugs against Giardia duodenalis.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Fayd'Herbe Keely, Lam Chun Kit, Hart Christopher J S, Skinner-Adams Tina S
Аннотация
BACKGROUND: Drug-combination therapies are needed to combat treatment refractory giardiasis. However, data describing the activity of combinations of currently used drugs against Giardia duodenalis are unavailable.
METHODS: The in vitro activity of combinations of currently used antigiardial drugs were investigated against G. duodenalis.
RESULTS: Combinations of metronidazole with albendazole or quinacrine, and quinacrine with nitazoxanide, behaved additively, whereas combinations of metronidazole with nitazoxanide, albendazole or quinacrine behaved synergistically. Combinations of albendazole with nitazoxanide behaved antagonistically.
CONCLUSIONS: While combinations of metronidazole with nitazoxanide, or albendazole with quinacrine, may be effective treatments of giardiasis, combinations of albendazole with nitazoxanide are likely to result in negative pharmacodynamic interactions.
METHODS: The in vitro activity of combinations of currently used antigiardial drugs were investigated against G. duodenalis.
RESULTS: Combinations of metronidazole with albendazole or quinacrine, and quinacrine with nitazoxanide, behaved additively, whereas combinations of metronidazole with nitazoxanide, albendazole or quinacrine behaved synergistically. Combinations of albendazole with nitazoxanide behaved antagonistically.
CONCLUSIONS: While combinations of metronidazole with nitazoxanide, or albendazole with quinacrine, may be effective treatments of giardiasis, combinations of albendazole with nitazoxanide are likely to result in negative pharmacodynamic interactions.