Zhonghua bing li xue za zhi = Chinese journal of pathology · 2014
[Interdigitating dendritic cell sarcoma/tumor: a clinicopathologic study].
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Pan Minhong, Gong Qixing, Fan Qinhe, Zhang Zhihong, Li Yang, Wang Cong
Аннотация
OBJECTIVE: To study the clinicopathologic characteristics and diagnostic criteria of interdigitating dendritic cell sarcoma/tumor (IDCS/T).
METHODS: The clinical features, histologic findings and results of immunohistochemical study in six cases of IDCS/T were analyzed, with review of literature.
RESULTS: The age of patients ranged from 20 to 68 years. The sites of involvement included lymph node, tonsil and soft tissue. Histologically, the tumor cells were arranged in sheets, fascicles or whorls and intimately admixed with abundant lymphocytes and plasma cells. They were oval to spindly in shape and contained pale eosinophilic cytoplasm, oval nuclei and distinct nucleoli.Immunohistochemical study showed that the tumor cells were positive for S-100 protein and CD68.
CONCLUSIONS: IDCS/T is a rare malignant tumor with poor prognosis. It carries distinctive histologic pattern and immunophenotype. The entity needs to be distinguished from follicular dendritic cell sarcoma/tumor, anaplastic large cell lymphoma and other spindle cell sarcomas in occurring soft tissue.
METHODS: The clinical features, histologic findings and results of immunohistochemical study in six cases of IDCS/T were analyzed, with review of literature.
RESULTS: The age of patients ranged from 20 to 68 years. The sites of involvement included lymph node, tonsil and soft tissue. Histologically, the tumor cells were arranged in sheets, fascicles or whorls and intimately admixed with abundant lymphocytes and plasma cells. They were oval to spindly in shape and contained pale eosinophilic cytoplasm, oval nuclei and distinct nucleoli.Immunohistochemical study showed that the tumor cells were positive for S-100 protein and CD68.
CONCLUSIONS: IDCS/T is a rare malignant tumor with poor prognosis. It carries distinctive histologic pattern and immunophenotype. The entity needs to be distinguished from follicular dendritic cell sarcoma/tumor, anaplastic large cell lymphoma and other spindle cell sarcomas in occurring soft tissue.
Предметные рубрики MeSH
AdultAgedAntigens, CDAntigens, Differentiation, MyelomonocyticDendritic Cell Sarcoma, FollicularDendritic Cell Sarcoma, InterdigitatingDiagnosis, DifferentialFemaleFollow-Up StudiesHistiocytoma, Malignant FibrousHistiocytosis, Langerhans-CellHumansLymph NodesLymphoma, Large-Cell, AnaplasticMaleMiddle AgedNeckS100 ProteinsSarcomaSoft Tissue NeoplasmsThighTonsillar NeoplasmsVimentinYoung AdultCD68 Molecule