Медицинская библиотека · Antimicrobial agents and chemotherapy · 2022
Echinocandins Susceptibility Patterns of 2,787 Yeast Isolates: Importance of the Thresholds for the Detection of FKS Mutations.
Desnos-Ollivier Marie, Bretagne Stéphane, Lortholary Olivier, Dromer Françoise, French Mycoses Study Group N. Brieu CH Aix, T. Chouaki , C. Damiani , A. Totet CHU Amiens, J. P. Bouchara , D. Chabasse , M. Pihet CHU Angers, S. Bland CH Annecy, V. Blanc CH Antibes, S. Branger CH Avignon, A. P. Bellanger , L. Millon CHU Besançon, C. Plassart CH Beauvais, I. Poilane Hôpital Jean Verdier, Bondy, I. Accoceberry , L. Delhaes , B. Couprie , F. Gabriel CH Bordeaux, J. Dunand , A. L. Roux , V. Sivadon-Tardy Hôpital Ambroise Paré, Boulogne Billancourt, F. Laurent CH, Bourg en Bresse, S. Legal , E. Moalic , G. Nevez , D. Quinio CHU Brest, M. Cariou CH Bretagne Sud, J. Bonhomme , C. Duhamel CHU, Caen, B. Podac CH, Chalon sur Saône, S. Lechatch CH, Charleville-Mézières, C. Soler Hopital d’Instruction des armées, Clamart, M. Cambon , C. Nourrisson , P. Poirier , D. Pons CHU, Clermont Ferrand, O. Augereau , I. Grawey CH, Colmar, N. Fauchet CHIC, Créteil, A. Bonnin , F. Dalle CHU, Dijon, P. Cahen , P. Honderlick CMC, Foch, N. Desbois , C. Miossec CHU, Fort de France, J. L. Hermann Hôpital Raymond Poincaré, Garches, M. Cornet , R. Grillot , B. Lebeau , D. Maubon , H. Pelloux CHU, Grenoble, M. Nicolas CHU, Guadeloupe, C. Aznar , D. Blanchet , J. F. Carod , M. Demar CHU, Guyane, A. Angoulvant Hôpital Bicêtre, le Kremlin Bicêtre, C. Ciupek CH, Le Mans, A. Gigandon Hôpital Marie Lannelongue, Le Plessis Robinson, B. Bouteille CH Limoges, E. Frealle , D. Poulain , B. Sendid CHU Lille, D. Dupont , J. Menotti , F. Persat , M.-A. Piens , M. Wallon CHU, Lyon, C. Cassagne , S. Ranque CHU, Marseille, T. Benoit-Cattin , L. Collet CH Mayotte, A. Fiacre CH Meaux, N. Bourgeois , L. Lachaud , P. Rispail , Y. Sterkers CHU, Montpellier, M. Machouart CHU, Nancy, F. Gay-Andrieu , P. Lepape , F. Morio CHU, Nantes, O. Moquet CH, Nevers, S. Lefrançois Hôpital Américain, Neuilly, M. Sasso CHU, Nimes, F. Reibel GH, Nord-Essone, M. Gari-Toussaint , L. Hasseine CHU Nice, L. Bret , D. Poisson CHR Orléans, S. Brun Hôpital Avicenne, Paris, C. Bonnal , C. Chochillon , S. Houzé Hôpital Bichat, Paris, A. Paugam Hôpital Cochin, Paris, N. Ait-Ammar , F. Botterel , R. Chouk CHU Henri Mondor, Paris, M. E. Bougnoux , E. Sitterle Hôpital Necker, Paris, A. Fekkar , R. Piarroux Hôpital Pitié Salpêtrière, Paris, J. Guitard , C. Hennequin , J.-L. Poirot Hôpital St Antoine, Paris, M. Gits-Muselli , S. Hamane , C. Lacroix Hôpital Saint Louis, Paris, S. Bonacorsi , P. Mariani Hôpital Robert Debré, Paris, D. Moissenet Hôpital Trousseau, Paris, C. Kauffmann-Lacroix , A. Minoza , E. Perraud , M. H. Rodier CHU Poitiers, G. Colonna CH, Porto Vecchio, A. Huguenin , D. Toubas CHU Reims, S. Chevrier , J. P. Gangneux , F. Robert-Gangneux , C. Guigen CHU Rennes, O. Belmonte , G. Hoarau , M. C. Jaffar Bandjee , J. Jaubert , S. Picot , N. Traversier CHU Réunion, L. Favennec , G. Gargala CHU, Rouen, N. Godineau , C. Tournus CH, St Denis, C. Mahinc , H. Raberin CHU, St Etienne, V. Letscher Bru CHU, Strasbourg, S. Cassaing CHU, Toulouse, P. Patoz CH Tourcoing, E. Bailly , J. Chandenier , G. Desoubeaux CHU Tours, F. Moreau CH Troyes, P. Munier CH Valence, E. Mazars CH Valenciennes, O. Eloy CH Versailles, E. Chachaty Institut Gustave Roussy, Villejuif
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАПеревод пока не подготовлен
Аннотация
Since echinocandins are recommended as first line therapy for invasive candidiasis, detection of resistance, mainly due to alteration in FKS protein, is of main interest. EUCAST AFST recommends testing both MIC of anidulafungin and micafungin, and breakpoints (BPs) have been proposed to detect echinocandin-resistant isolates. We analyzed MIC distribution for all three available echinocandins of 2,787 clinical yeast isolates corresponding to 5 common and 16 rare yeast species, using the standardized EUCAST method for anidulafungin and modified for caspofungin and micafungin (AM3-MIC). In our database, 64 isolates of common pathogenic species were resistant to anidulafungin, according to the EUCAST BP, and/or to caspofungin, using our previously published threshold (AM3-MIC ≥ 0.5 mg/L). Among these 64 isolates, 50 exhibited 21 different FKS mutations. We analyzed the capacity of caspofungin AM3-MIC and anidulafungin MIC determination in detecting isolates with FKS mutation. They were always identified using caspofungin AM3-MIC and the local threshold while some isolates were misclassified using anidulafungin MIC and EUCAST threshold. However, both methods misclassified four wild-type C. glabrata as resistant. Based on a large data set from a single center, the use of AM3-MIC testing for caspofungin looks promising in identifying non-wild-type C. albicans, C. tropicalis and P. kudiravzevii isolates, but additional multicenter comparison is mandatory to conclude on the possible superiority of AM3-MIC testing compared to the EUCAST method.
Для цитирования: Desnos-Ollivier Marie, Bretagne Stéphane, Lortholary Olivier, Dromer Françoise, French Mycoses Study Group N. Brieu CH Aix, T. Chouaki , C. Damiani , A. Totet CHU Amiens, J. P. Bouchara , D. Chabasse , M. Pihet CHU Angers, S. Bland CH Annecy, V. Blanc CH Antibes, S. Branger CH Avignon, A. P. Bellanger , L. Millon CHU Besançon, C. Plassart CH Beauvais, I. Poilane Hôpital Jean Verdier, Bondy, I. Accoceberry , L. Delhaes , B. Couprie , F. Gabriel CH Bordeaux, J. Dunand , A. L. Roux , V. Sivadon-Tardy Hôpital Ambroise Paré, Boulogne Billancourt, F. Laurent CH, Bourg en Bresse, S. Legal , E. Moalic , G. Nevez , D. Quinio CHU Brest, M. Cariou CH Bretagne Sud, J. Bonhomme , C. Duhamel CHU, Caen, B. Podac CH, Chalon sur Saône, S. Lechatch CH, Charleville-Mézières, C. Soler Hopital d’Instruction des armées, Clamart, M. Cambon , C. Nourrisson , P. Poirier , D. Pons CHU, Clermont Ferrand, O. Augereau , I. Grawey CH, Colmar, N. Fauchet CHIC, Créteil, A. Bonnin , F. Dalle CHU, Dijon, P. Cahen , P. Honderlick CMC, Foch, N. Desbois , C. Miossec CHU, Fort de France, J. L. Hermann Hôpital Raymond Poincaré, Garches, M. Cornet , R. Grillot , B. Lebeau , D. Maubon , H. Pelloux CHU, Grenoble, M. Nicolas CHU, Guadeloupe, C. Aznar , D. Blanchet , J. F. Carod , M. Demar CHU, Guyane, A. Angoulvant Hôpital Bicêtre, le Kremlin Bicêtre, C. Ciupek CH, Le Mans, A. Gigandon Hôpital Marie Lannelongue, Le Plessis Robinson, B. Bouteille CH Limoges, E. Frealle , D. Poulain , B. Sendid CHU Lille, D. Dupont , J. Menotti , F. Persat , M.-A. Piens , M. Wallon CHU, Lyon, C. Cassagne , S. Ranque CHU, Marseille, T. Benoit-Cattin , L. Collet CH Mayotte, A. Fiacre CH Meaux, N. Bourgeois , L. Lachaud , P. Rispail , Y. Sterkers CHU, Montpellier, M. Machouart CHU, Nancy, F. Gay-Andrieu , P. Lepape , F. Morio CHU, Nantes, O. Moquet CH, Nevers, S. Lefrançois Hôpital Américain, Neuilly, M. Sasso CHU, Nimes, F. Reibel GH, Nord-Essone, M. Gari-Toussaint , L. Hasseine CHU Nice, L. Bret , D. Poisson CHR Orléans, S. Brun Hôpital Avicenne, Paris, C. Bonnal , C. Chochillon , S. Houzé Hôpital Bichat, Paris, A. Paugam Hôpital Cochin, Paris, N. Ait-Ammar , F. Botterel , R. Chouk CHU Henri Mondor, Paris, M. E. Bougnoux , E. Sitterle Hôpital Necker, Paris, A. Fekkar , R. Piarroux Hôpital Pitié Salpêtrière, Paris, J. Guitard , C. Hennequin , J.-L. Poirot Hôpital St Antoine, Paris, M. Gits-Muselli , S. Hamane , C. Lacroix Hôpital Saint Louis, Paris, S. Bonacorsi , P. Mariani Hôpital Robert Debré, Paris, D. Moissenet Hôpital Trousseau, Paris, C. Kauffmann-Lacroix , A. Minoza , E. Perraud , M. H. Rodier CHU Poitiers, G. Colonna CH, Porto Vecchio, A. Huguenin , D. Toubas CHU Reims, S. Chevrier , J. P. Gangneux , F. Robert-Gangneux , C. Guigen CHU Rennes, O. Belmonte , G. Hoarau , M. C. Jaffar Bandjee , J. Jaubert , S. Picot , N. Traversier CHU Réunion, L. Favennec , G. Gargala CHU, Rouen, N. Godineau , C. Tournus CH, St Denis, C. Mahinc , H. Raberin CHU, St Etienne, V. Letscher Bru CHU, Strasbourg, S. Cassaing CHU, Toulouse, P. Patoz CH Tourcoing, E. Bailly , J. Chandenier , G. Desoubeaux CHU Tours, F. Moreau CH Troyes, P. Munier CH Valence, E. Mazars CH Valenciennes, O. Eloy CH Versailles, E. Chachaty Institut Gustave Roussy, Villejuif. Echinocandins Susceptibility Patterns of 2,787 Yeast Isolates: Importance of the Thresholds for the Detection of FKS Mutations.. Antimicrobial agents and chemotherapy. 2022. DOI: 10.1128/aac.01725-21.
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