Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
Microbial Metabolite Inspired β-Peptide Polymers Displaying Potent and Selective Antifungal Activity.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Zhang Donghui, Shi Chao, Cong Zihao, Chen Qi, Bi Yufang, Zhang Junyu, Ma Kaiqian, Liu Shiqi, Gu Jiawei, Chen Minzhang, Lu Ziyi, Zhang Haodong, Xie Jiayang, Xiao Ximian, Liu Longqiang, Jiang Weinan, Shao Ning, Chen Sheng, Zhou Min, Shao Xiaoyan, Dai Yidong, Li Maoquan, Zhang Lixin, Liu Runhui
Аннотация
Potent and selective antifungal agents are urgently needed due to the quick increase of serious invasive fungal infections and the limited antifungal drugs available. Microbial metabolites have been a rich source of antimicrobial agents and have inspired the authors to design and obtain potent and selective antifungal agents, poly(DL-diaminopropionic acid) (PDAP) from the ring-opening polymerization of β-amino acid N-thiocarboxyanhydrides, by mimicking ε-poly-lysine. PDAP kills fungal cells by penetrating the fungal cytoplasm, generating reactive oxygen, and inducing fungal apoptosis. The optimal PDAP displays potent antifungal activity with minimum inhibitory concentration as low as 0.4 µg mL-1 against Candida albicans, negligible hemolysis and cytotoxicity, and no susceptibility to antifungal resistance. In addition, PDAP effectively inhibits the formation of fungal biofilms and eradicates the mature biofilms. In vivo studies show that PDAP is safe and effective in treating fungal keratitis, which suggests PDAPs as promising new antifungal agents.