Parathyroid Retrospective Analysis of Neoplasms Incidence (pTRANI Study): An Italian Multicenter Study on Parathyroid Carcinoma and Atypical Parathyroid Tumour.
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Ошибки и ограничения
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Gurrado Angela, Pasculli Alessandro, Avenia Nicola, Bellantone Rocco, Boniardi Marco, Merante Boschin Isabella, Calò Pietro Giorgio, Camandona Michele, Cavallaro Giuseppe, Cianchi Fabio, Conzo Giovanni, D'Andrea Vito, De Crea Carmela, De Pasquale Loredana, Del Rio Paolo, Di Meo Giovanna, Dionigi Gianlorenzo, Dobrinja Chiara, Docimo Giovanni, Famà Fausto, Galimberti Attilio, Giacomelli Laura, Graceffa Giuseppa, Iacobone Maurizio, Innaro Nadia, Lombardi Celestino Pio, Materazzi Gabriele, Medas Fabio, Mullineris Barbara, Oragano Luigi, Palestini Nicola, Perigli Giuliano, Pezzolla Angela, Prete Francesco Paolo, Raffaelli Marco, Renzulli Giuseppina, Rosato Lodovico, Scerrino Gregorio, Sgaramella Lucia Ilaria, Sorrenti Salvatore, Testini Carlotta, Veroux Massimiliano, Gasparri Guido, Testini Mario, pTRANI Study Group
Аннотация
METHODS: All relevant information was collected about PC and APT patients treated between 2009 and 2021.
RESULTS: Among 8361 parathyroidectomies, 351 patients (mean age 59.0 ± 14.5; F = 210, 59.8%) were divided into the APT (n = 226, 2.8%) and PC group (n = 125, 1.5%). PC showed significantly higher rates (p < 0.05) of bone involvement, abdominal, and neurological symptoms than APT (48.8% vs. 35.0%, 17.6% vs. 7.1%, 13.6% vs. 5.3%, respectively). Ultrasound (US) diameter >3 cm (30.9% vs. 19.3%, p = 0.049) was significantly more common in the PC. A significantly higher frequency of local recurrences was observed in the PC (8.0% vs. 2.7%, p = 0.022). Mortality due to consequences of cancer or uncontrolled hyperparathyroidism was 3.3%.
CONCLUSIONS: Symptomatic hyperparathyroidism, high PTH and albumin-corrected serum calcium values, and a US diameter >3 cm may be considered features differentiating PC from APT. 2022 WHO criteria did not impact the diagnosis.