PCN reports : psychiatry and clinical neurosciences · 2024
Obsessive-compulsive disorder induced by donepezil in a patient with Alzheimer's disease.
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Echizen Kohei, Hirose Daisuke
Аннотация
BACKGROUND: Donepezil, an acetylcholinesterase inhibitor commonly used to treat Alzheimer's disease (AD), is generally well tolerated. There have been no previous reports on donepezil-induced obsessive-compulsive disorder (OCD).
CASE PRESENTATION: The patient, a retired man in his 70s diagnosed with AD, displayed OCD symptoms following donepezil initiation, exacerbating post-stroke-specifically, a cerebral infarction in the right posterior limb of the internal capsule. Remarkably, the symptoms abated upon discontinuation of donepezil.
CONCLUSION: Caution should be exercised when using donepezil in patients with a history of stroke.
CASE PRESENTATION: The patient, a retired man in his 70s diagnosed with AD, displayed OCD symptoms following donepezil initiation, exacerbating post-stroke-specifically, a cerebral infarction in the right posterior limb of the internal capsule. Remarkably, the symptoms abated upon discontinuation of donepezil.
CONCLUSION: Caution should be exercised when using donepezil in patients with a history of stroke.