Brain : a journal of neurology · 2024
Establishing connectivity through microdissections of midbrain stimulation-related neural circuits.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Skandalakis Georgios P, Neudorfer Clemens, Payne Caitlin A, Bond Evalina, Tavakkoli Armin D, Barrios-Martinez Jessica, Trutti Anne C, Koutsarnakis Christos, Coenen Volker A, Komaitis Spyridon, Hadjipanayis Constantinos G, Stranjalis George, Yeh Fang-Cheng, Banihashemi Layla, Hong Jennifer, Lozano Andres M, Kogan Michael, Horn Andreas, Evans Linton T, Kalyvas Aristotelis
Аннотация
Comprehensive understanding of the neural circuits involving the ventral tegmental area is essential for elucidating the anatomofunctional mechanisms governing human behaviour, in addition to the therapeutic and adverse effects of deep brain stimulation for neuropsychiatric diseases. Although the ventral tegmental area has been targeted successfully with deep brain stimulation for different neuropsychiatric diseases, the axonal connectivity of the region is not fully understood. Here, using fibre microdissections in human cadaveric hemispheres, population-based high-definition fibre tractography and previously reported deep brain stimulation hotspots, we find that the ventral tegmental area participates in an intricate network involving the serotonergic pontine nuclei, basal ganglia, limbic system, basal forebrain and prefrontal cortex, which is implicated in the treatment of obsessive-compulsive disorder, major depressive disorder, Alzheimer's disease, cluster headaches and aggressive behaviours.