Chemical research in toxicology · 2022
Adenanthin Is an Efficient Inhibitor of Peroxiredoxins from Pathogens, Inhibits Bacterial Growth, and Potentiates Antibiotic Activities.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Dos Santos Melina Cardoso, Tairum Carlos Abrunhosa, Cabrera Vitoria Isabela Montanhero, Guimarães Cauz Ana Carolina, Ribeiro Luiz Fernando, Toledo Junior José Carlos, Toyama Marcos Hikari, Lago João Henrique Ghilardi, Brocchi Marcelo, Netto Luis Eduardo Soares, de Oliveira Marcos Antonio
Аннотация
The emergence and re-emergence of bacterial strains resistant to multiple drugs represent a global health threat, and the search for novel biological targets is a worldwide concern. AhpC are enzymes involved in bacterial redox homeostasis by metabolizing diverse kinds of hydroperoxides. In pathogenic bacteria, AhpC are related to several functions, as some isoforms are characterized as virulence factors. However, no inhibitor has been systematically evaluated to date. Here we show that the natural ent-kaurane Adenanthin (Adn) efficiently inhibits AhpC and molecular interactions were explored by computer assisted simulations. Additionally, Adn interferes with growth and potentializes the effect of antibiotics (kanamycin and PMBN), positioning Adn as a promising compound to treat infections caused by multiresistant bacterial strains.