[Cytomegaloviral inclusions detected in the seminal vesicle, ductus deferens and lungs in an autopsy case of lung cancer].

We report a case of cytomegalovirus infection of the seminal vesicle and ductus deferens in a 32-year-old Japanese man with papillary adenocarcinoma of the lung. Although the lungs are usually a target organ of cytomegalovirus infection, most organs can be involved. However, the male reproductive system has rarely been reported infected with the virus. H.E. sections of our case showed cytomegaloviral inclusions in many ductal epithelia of the seminal vesicle and ductus deferens as well as macrophages of the lungs. Immunohistochemistry using monoclonal antibody to cytomegalovirus disclosed viral antigenicity in these infected cells. Electron microscopy recovered enlarged infected cells packed with viral nucleocapsids approximately 100 nm in size. These nucleocapsids were enveloped in the cytoplasm and consistent with the Herpesviridae family. To our knowledge, our case is the first report of cytomegalovirus infection of the seminal vesicle and ductus deferens in the English and Japanese literature.