Eating and weight disorders : EWD · 2003
Plasma ghrelin levels and malnutrition: a comparison of two etiologies.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Krsek M, Rosická M, Papezová H, Krízová J, Kotrlíková E, Haluz'k M, Justová V, Lacinová Z, Jarkovská Z
Аннотация
Ghrelin is a peptide hormone that is involved in regulating growth hormone secretion as well as food intake and energy homeostasis. The aim of this study was to compare changes in plasma ghrelin levels in patients with malnutrition due to anorexia nervosa (AN) or short bowel syndrome (SBS). Blood samples for laboratory analyses were taken from 16 AN patients (plus 13 comparable healthy controls) and 27 SBS patients (plus 13 comparable healthy controls) after an overnight fast. In comparison with their respective control groups, plasma ghrelin levels were increased in the AN patients (p < 0.05) and significantly decreased in the patients with SBS (p < 0.01). These results suggest that quantitative ghrelin secretion in the gut wall is important in determining ghrelin concentrations in the systemic circulation.
Предметные рубрики MeSH
Adipose TissueAdultAnorexia NervosaBody CompositionBody Mass IndexCase-Control StudiesFastingFemaleGhrelinGrowth HormoneHumansInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor ILeptinMaleMalnutritionMiddle AgedNutrition AssessmentPeptide HormonesReceptors, Cell SurfaceReceptors, LeptinSex CharacteristicsShort Bowel SyndromeSkinfold Thickness