Медицинская библиотека · Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2003

[Expression of connective tissue growth factor gene in the hypertrophic scar and keloid tissue].

Liu Jian-yi, Li Shi-rong, Ji Shu-xing

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Аннотация

OBJECTIVE

To explore the effect of connective tissue growth factor on the pathogenesis of hypertrophic scar and keloid tissue.

METHODS

The content of hydroxyproline was determined and the expression of connective tissue growth factor gene was detected by the reverse transcription-polymerase chain reaction and image analysis technique in 5 normal skins, 15 hypertrophic scars and 7 keloid tissues.

RESULTS

The contents of hydroxyproline in the hypertrophic scar (84.10 +/- 1.76) and keloid tissue (92.38 +/- 2.04) were significantly higher than that of normal skin tissue (26.52 +/- 4.10) (P < 0.01). The index of connective tissue growth factor mRNA in the hypertrophic scar (0.78 +/- 0.63) and keloid tissue (0.84 +/- 0.04) were higher than that of normal skin tissue (0.09 +/- 0.25) (P < 0.01).

CONCLUSION

Connective tissue growth factor may play an important role in promoting the fibrotic process of hypertrophic scar and keloid tissue.

Для цитирования: Liu Jian-yi, Li Shi-rong, Ji Shu-xing. [Expression of connective tissue growth factor gene in the hypertrophic scar and keloid tissue].. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery. 2003.

Предметные рубрики MeSH

Adolescent Adult Cicatrix, Hypertrophic Connective Tissue Growth Factor Female Gene Expression Humans Hydroxyproline Immediate-Early Proteins Intercellular Signaling Peptides and Proteins Keloid Male Middle Aged RNA, Messenger Reverse Transcriptase Polymerase Chain Reaction Skin Transforming Growth Factor beta

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