Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery · 2002
[Effects of microfilaments on the expression of collagenases and tissue inhibitor of metalloproteinases-1 in fibroblasts].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Gu Haifeng, He Qinglian, Lin Zihao, Liu Qi, Zhang Xingmei
Аннотация
OBJECTIVE: To investigate the roles of microfilaments in the expression of collagenase and TIMP-1 in normal and hypertrophic scar.
METHODS: Cell culture and Northern blot hybridization methods were used in this study.
RESULTS: After the disruption of microfilaments with cytochalasin B, mRNA contents of collagenase and TIMP-1 both increased significantly in normal and hypertrophic scar fibroblasts.
CONCLUSION: The result suggest that the microfilament cytoskeleton may regulate the synthesis and degradation of ECM, which may be a mechanism of gene regulation during wound healing.
METHODS: Cell culture and Northern blot hybridization methods were used in this study.
RESULTS: After the disruption of microfilaments with cytochalasin B, mRNA contents of collagenase and TIMP-1 both increased significantly in normal and hypertrophic scar fibroblasts.
CONCLUSION: The result suggest that the microfilament cytoskeleton may regulate the synthesis and degradation of ECM, which may be a mechanism of gene regulation during wound healing.