Медицинская библиотека · Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery · 2002

[Effects of microfilaments on the expression of collagenases and tissue inhibitor of metalloproteinases-1 in fibroblasts].

Gu Haifeng, He Qinglian, Lin Zihao, Liu Qi, Zhang Xingmei

Аннотация на английскомСтатьяПеревод пока не подготовлен

Аннотация

OBJECTIVE

To investigate the roles of microfilaments in the expression of collagenase and TIMP-1 in normal and hypertrophic scar.

METHODS

Cell culture and Northern blot hybridization methods were used in this study.

RESULTS

After the disruption of microfilaments with cytochalasin B, mRNA contents of collagenase and TIMP-1 both increased significantly in normal and hypertrophic scar fibroblasts.

CONCLUSION

The result suggest that the microfilament cytoskeleton may regulate the synthesis and degradation of ECM, which may be a mechanism of gene regulation during wound healing.

Для цитирования: Gu Haifeng, He Qinglian, Lin Zihao, Liu Qi, Zhang Xingmei. [Effects of microfilaments on the expression of collagenases and tissue inhibitor of metalloproteinases-1 in fibroblasts].. Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery. 2002.

Предметные рубрики MeSH

Actin Cytoskeleton Cells, Cultured Collagenases Fibroblasts Humans RNA, Messenger Tissue Inhibitor of Metalloproteinase-1 Wound Healing

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