Ocular immunology and inflammation · 2008
Ophthalmic manifestations of immune reconstitution inflammatory syndrome associated with Cryptococcus neoformans.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Khurana Rahul N, Javaheri Micheal, Rao Narsing
Аннотация
PURPOSE: To describe the ophthalmic manifestations of immune reconstitution inflammatory syndrome (IRIS) associated with Cryptococcus neoformans.
METHODS: Four HIV-positive patients on highly active anti-retroviral therapy (HAART) presented with marked optic disk swelling.
RESULTS: Three months after the episode of IRIS, 2 of the patients maintained 20/20 visual acuity whose elevated intracranial pressure (ICP) was successfully managed, while 2 patients visual acuities were worse than 20/400 whose ICP was persistently elevated.
CONCLUSION: Cryptococcus is another opportunistic infectious organism associated with IRIS with ophthalmic manifestations. Ophthalmologists have the opportunity to play a key role in the early diagnosis and management to prevent serious visual loss.
METHODS: Four HIV-positive patients on highly active anti-retroviral therapy (HAART) presented with marked optic disk swelling.
RESULTS: Three months after the episode of IRIS, 2 of the patients maintained 20/20 visual acuity whose elevated intracranial pressure (ICP) was successfully managed, while 2 patients visual acuities were worse than 20/400 whose ICP was persistently elevated.
CONCLUSION: Cryptococcus is another opportunistic infectious organism associated with IRIS with ophthalmic manifestations. Ophthalmologists have the opportunity to play a key role in the early diagnosis and management to prevent serious visual loss.
Предметные рубрики MeSH
AIDS-Related Opportunistic InfectionsAcetazolamideAdultAntigens, FungalAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCryptococcosisCryptococcus neoformansDiureticsEye Infections, FungalFemaleHIV SeropositivityHumansImmune Reconstitution Inflammatory SyndromeIntracranial HypertensionMaleMiddle AgedPapilledemaRetinal HemorrhageRetrospective StudiesSpinal PunctureViral Load