Public health weekly report · 2026
Nationwide Measles Seroprevalence in the Republic of Korea, 2023.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kim Ah-Ra, Kee Seung-Jung, Choi Hyun-Woo, Shin Hyun Sook, Lee Su Jeong, Kang Min Jeong, Do Hyeon Nam, Lee June-Woo, Jeong Hye-Sook
Аннотация
OBJECTIVES: Although measles-mumps-rubella vaccination coverage remains above 95% in the Republic of Korea, imported measles cases continue to occur. This study aimed to assess the population-level immunity to measles to inform the evaluation of the national immunization program and to identify potential immunity gaps relevant to outbreak risk.
METHODS: Serum specimens were collected from 1,719 individuals aged 0-93 years (birth cohorts 1930-2023) across six regions. Anti-measles virus IgG binding antibodies were measured using an enzyme-linked immunosorbent assay (ELISA). A subset of 286 specimens was further analyzed using plaque reduction neutralization test (PRNT). Antibody concentrations were standardized to the World Health Organization 3rd International Standard for Anti-Measles (NIBSC 97/648; 3,000 mIU/mL).
RESULTS: Overall, ELISA seropositivity was 75.9% across all ages and increased to 77.4% after exclusion of infants aged <1 year. Among participants aged ≥1 year, ELISA geometric mean titers (GMTs) were lowest in adolescents and young adults (approximately 10-29 years), ranging from 154.1 to 273.5 mIU/mL. PRNT seropositivity was ≥70% across all 10-year age groups among participants aged ≥1 year, and the age-group-specific pattern of neutralizing antibody GMTs was broadly consistent with the susceptible age groups identified in the binding antibody analysis.
CONCLUSIONS: This national serosurvey identified reduced binding and neutralizing antibody levels in parts of the adolescent and early-adult populations, indicating a possible immunity gap (immune pocket). Given the age distribution of measles cases reported during 2024-2025, these findings highlight the need for strengthened surveillance and systematic review of vaccination history in these age groups to help reduce secondary transmission at the community level.
METHODS: Serum specimens were collected from 1,719 individuals aged 0-93 years (birth cohorts 1930-2023) across six regions. Anti-measles virus IgG binding antibodies were measured using an enzyme-linked immunosorbent assay (ELISA). A subset of 286 specimens was further analyzed using plaque reduction neutralization test (PRNT). Antibody concentrations were standardized to the World Health Organization 3rd International Standard for Anti-Measles (NIBSC 97/648; 3,000 mIU/mL).
RESULTS: Overall, ELISA seropositivity was 75.9% across all ages and increased to 77.4% after exclusion of infants aged <1 year. Among participants aged ≥1 year, ELISA geometric mean titers (GMTs) were lowest in adolescents and young adults (approximately 10-29 years), ranging from 154.1 to 273.5 mIU/mL. PRNT seropositivity was ≥70% across all 10-year age groups among participants aged ≥1 year, and the age-group-specific pattern of neutralizing antibody GMTs was broadly consistent with the susceptible age groups identified in the binding antibody analysis.
CONCLUSIONS: This national serosurvey identified reduced binding and neutralizing antibody levels in parts of the adolescent and early-adult populations, indicating a possible immunity gap (immune pocket). Given the age distribution of measles cases reported during 2024-2025, these findings highlight the need for strengthened surveillance and systematic review of vaccination history in these age groups to help reduce secondary transmission at the community level.