An update on the GE (Gerbich) blood group system.

Antibodies to antigens of the GE (Gerbich) blood group system are not encountered in transfusion center blood banks on a daily basis but are regular guests at reference laboratories. In this review, we present an update on the information on GE antigens and alleles that have been published since the release of the previous system review in 2010. Additionally, information on the clinical relevance of GE antibodies for both transfusion and hemolytic disease of the fetus and newborn and recent discoveries related to functional aspects of the glycophorin C and glycophorin D proteins have been included.