[Investigation on mice of the common toxicity of methyl-tert-butyl ether, substance for contact chemical litholys of cholesterol stones in a gallbladder].

INTRODUCTION

Methyl-tert-butyl ether (MTBE) is used at contact chemical dissolution (CCD) of cholesterol gallstones since 1981. However no abroad, no in Russia on MTBE the sanction as on a medical product is not received.

AIM: to determine parameters of common toxicity MTBE at white mice.

MATERIALS AND

METHODS

MTBE entered per se to white mice intrastomach (Litchfield-Wilcocson). Calculations of average lethal dozes carried out. Batching carried out on weight of substance, taking into account its density of 0.74 g/sm2, and expressed in mg/kg of weight of a body of animals. Research carried out together with Institute of toxicology (Saint Petersburg, Russia).

RESULTS

The period of supervision was 14 days. Lethal, time of destruction, semiology of a poisoning carried out before introduction, for 7 and 14 days of supervision, opening and macroscopical research of all perishing and survived animals--at the end of research. The death of animals at intrastomach introduction of fatal dozes MTBE (more than 5 g/kg) was observed within 1.5-5 hours from the moment of introduction at the phenomena of slackness, devocalization and a paralysis. Semiology was of the deep narcotic intoxication. Opening of the died animals has revealed: attributes venous full bloods of the internal bodies, subpleural haemorrhages, fine haemorrhages in an oblong brain and the big hemispheres of a bark. At the animals receiving less 5 g/kg, in the first day block, slackness, drowsiness, decrease of consumption of a forage and water were marked. In other days they did not differ from those at animals of control group.

CONCLUSION

Sharp intrastomach introduction MTBE does not cause macroscopical changes internal and glandulars bodies, a brain, and also mucous of a stomach and an intestines.