International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
Local wastewater monitoring as a complementary tool in a mumps outbreak investigation in the Netherlands: A proof-of-concept study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Joosten Maja, Dijkstra Aart C, de Jong Maarten, Schilperoort Remy P S, Langeveld Jeroen, Prins Marlous, Sips Gregorius J, Fanoy Ewout, de Graaf Miranda, Medema Gertjan, Jaspers Loes
Аннотация
BACKGROUND: A recent outbreak of mumps showed a concerningly low number of classical disease notifications, prompting evaluation of the efficacy of local wastewater monitoring.
METHODS: Suspected mumps cases were recorded by local General Practitioner practices (n = 13) for 20 weeks, and laboratory-reported notifications were collected. Local wastewater monitoring using passive samplers was deployed downstream of a confirmed case and their school, and in wastewater pumping stations serving the involved and neighbouring towns. Wastewater samples were analysed using reverse transcription polymerase chain reaction.
RESULTS: General Practitioners reported 50 suspected patients, of which 24 were confirmed. The passive sampler near the confirmed case detected virus RNA directly postdiagnosis, followed by a negative signal afterwards, while samplers at the school and the local pumping station detected rising concentrations as more cases were reported. Samplers in neighbouring towns showed further spread, including a town with no reported cases.
CONCLUSION: This study demonstrates the first successful proof-of-concept for local wastewater monitoring of mumps and indicates a possible correlation between wastewater and clinical monitoring. These results suggest a role for local wastewater monitoring using passive samplers in creating situational awareness during an outbreak, even when cases are not reported.
METHODS: Suspected mumps cases were recorded by local General Practitioner practices (n = 13) for 20 weeks, and laboratory-reported notifications were collected. Local wastewater monitoring using passive samplers was deployed downstream of a confirmed case and their school, and in wastewater pumping stations serving the involved and neighbouring towns. Wastewater samples were analysed using reverse transcription polymerase chain reaction.
RESULTS: General Practitioners reported 50 suspected patients, of which 24 were confirmed. The passive sampler near the confirmed case detected virus RNA directly postdiagnosis, followed by a negative signal afterwards, while samplers at the school and the local pumping station detected rising concentrations as more cases were reported. Samplers in neighbouring towns showed further spread, including a town with no reported cases.
CONCLUSION: This study demonstrates the first successful proof-of-concept for local wastewater monitoring of mumps and indicates a possible correlation between wastewater and clinical monitoring. These results suggest a role for local wastewater monitoring using passive samplers in creating situational awareness during an outbreak, even when cases are not reported.