Molecular genetics & genomic medicine · 2021
Gain-of-function mutation Met136Val in SCN8A may not be a common cause of trigeminal neuralgia.
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Sekula Raymond F, Deeley Kathleen, Denwood Hayley, Vieira Alexandre R
Аннотация
BACKGROUND: The Met136Val mutation in SCN8A was described in a case of trigeminal neuralgia but no frequency among affected individuals was provided.
METHODS: Direct sequencing of 123 individuals diagnosed with classic trigeminal neuralgia was performed aimed to detect the Met136Val change.
RESULTS: No cases of classical trigeminal neuralgia studied had the Met136Val mutation in SCN8A.
CONCLUSION: Met136Val mutation in SCN8A is not a frequent cause of classical trigeminal neuralgia.
METHODS: Direct sequencing of 123 individuals diagnosed with classic trigeminal neuralgia was performed aimed to detect the Met136Val change.
RESULTS: No cases of classical trigeminal neuralgia studied had the Met136Val mutation in SCN8A.
CONCLUSION: Met136Val mutation in SCN8A is not a frequent cause of classical trigeminal neuralgia.