Incidence of SARS-CoV-2 infection among COVID-19 vaccinated and unvaccinated healthcare personnel, first responders, and other essential and frontline workers: Eight US locations, January-September 2021.
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Naleway Allison L, Grant Lauren, Caban-Martinez Alberto J, Wesley Meredith G, Burgess Jefferey L, Groover Kimberly, Gaglani Manjusha, Yoon Sarang K, Tyner Harmony L, Meece Jennifer, Kuntz Jennifer L, Yoo Young M, Schaefer-Solle Natasha, Olsho Lauren E W, Gerald Joe K, Rose Spencer, Thiese Matthew S, Lundgren Jessica, Groom Holly C, Mak Josephine, Louzado Feliciano Paola, Edwards Laura J, Lutrick Karen, Dunnigan Kayan, Phillips Andrew L, Lamberte Julie Mayo, Noriega Roger, Sokol Brian E, Odean Marilyn, Ellingson Katherine D, Smith Michael, Hegmann Kurt T, Respet Karley, Dickerson Monica, Cruz Alexandra, Fleary Deanna E, Murthy Kempapura, Hunt Angela, Azziz-Baumgartner Eduardo, Gallimore-Wilson Damena, Harder Jenna A, Odame-Bamfo Leah, Viergutz Jennifer, Arvay Melissa, Jones John M, Mistry Peenaz, Thompson Mark G, Fowlkes Ashley L
Аннотация
METHODS: We analyzed data from a prospective frontline worker cohort to estimate the incidence of COVID-19 by month as well as the association of COVID-19 vaccination, occupation, demographics, physical distancing, and mask use with infection risk. Participants completed baseline and quarterly surveys, and each week self-collected mid-turbinate nasal swabs and reported symptoms.
RESULTS: Among 1018 unvaccinated and 3531 fully vaccinated workers, the monthly incidence of laboratory-confirmed SARS-CoV-2 infection in January 2021 was 13.9 (95% confidence interval [CI]: 10.4-17.4), declining to 0.5 (95% CI -0.4-1.4) per 1000 person-weeks in June. By September 2021, when the Delta variant predominated, incidence had once again risen to 13.6 (95% CI 7.8-19.4) per 1000 person-weeks. In contrast, there was no reportable incidence among fully vaccinated participants at the end of January 2021, and incidence remained low until September 2021 when it rose modestly to 4.1 (95% CI 1.9-3.8) per 1000. Below average facemask use was associated with a higher risk of infection for unvaccinated participants during exposure to persons who may have COVID-19 and vaccinated participants during hours in the community.
CONCLUSIONS: COVID-19 vaccination was significantly associated with a lower risk of SARS-CoV-2 infection despite Delta variant predominance. Our data demonstrate the added protective benefit of facemask use among both unvaccinated and vaccinated frontline workers.