Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019: A Prospective Cohort Study of 46 000 Healthcare Workers.
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Kristensen Jonas Henrik, Bo Hasselbalch Rasmus, Pries-Heje Mia, Nielsen Pernille Brok, Dehlbæk Knudsen Andreas, Fogh Kamille, Boesgaard Norsk Jakob, Eiken Aleksander, Andersen Ove, Fischer Thea Kølsen, Juul Jensen Claus Antonio, Torp-Pedersen Christian, Rungby Jørgen, Ditlev Sisse Bolm, Hageman Ida, Møgelvang Rasmus, Gybel-Brask Mikkel, Dessau Ram Benny, Sørensen Erik, Harritshøj Lene, Folke Fredrik, Engel Møller Maria Elizabeth, Benfield Thomas, Ullum Henrik, Sværke Jørgensen Charlotte, Rye Ostrowski Sisse, Dam Nielsen Susanne, Bundgaard Henning, Iversen Kasper
Аннотация
METHODS: A cohort of 46 112 healthcare workers were tested for antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and filled in a survey on COVID-19 symptoms, hospitalization, and influenza vaccination.
RESULTS: The risk ratio of hospitalization due to SARS-CoV-2 for influenza vaccinated compared with unvaccinated participants was 1.00 for the seasonal vaccination in 2019/2020 (confidence interval, .56-1.78, P = 1.00). Likewise, no clinical effect of influenza vaccination on development of antibodies against SARS-CoV-2 was found.
CONCLUSIONS: The present findings indicate that influenza vaccination does not affect the risk of SARS-CoV-2 infection or COVID-19.