The Journal of experimental medicine · 2021
Immunotherapy during the acute SHIV infection of macaques confers long-term suppression of viremia.
СтатьяПоддержка NIH: внешняя программаResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Nishimura Yoshiaki, Donau Olivia K, Dias Joana, Ferrando-Martinez Sara, Jesteadt Eric, Sadjadpour Reza, Gautam Rajeev, Buckler-White Alicia, Geleziunas Romas, Koup Richard A, Nussenzweig Michel C, Martin Malcolm A
Аннотация
We report that combination bNAb immunotherapy initiated on day 3 post-infection (PI) maintained durable CD8+ T cell-mediated suppression of SHIVAD8 viremia and preinoculation levels of CD4+ T cells in 9 of 13 treated monkeys during nearly 6 yr of observation, as assessed by successive CD8+ T cell-depletion experiments. In an extension of that study, two treatment interventions (bNAbs alone or cART plus bNAbs) beginning on week 2 PI were conducted and conferred controller status to 7 of 12 monkeys that was also dependent on control mediated by CD8+ cells. However, the median time to suppression of plasma viremia following intervention on week 2 was markedly delayed (85 wk) compared with combination bNAb immunotherapy initiated on day 3 (39 wk). In both cases, the principal correlate of virus control was the induction of CD8+ T cellular immunity.