Journal of neuroimmunology · 2004
TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: links to HIV-1-associated dementia.
Сравнительное исследованиеСтатьяПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
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Ryan Lisa A, Peng Hui, Erichsen David A, Huang Yunlong, Persidsky Yuri, Zhou You, Gendelman Howard E, Zheng Jialin
Аннотация
TNF-related apoptosis-inducing ligand (TRAIL) is a type II integral membrane protein that interacts with multiple receptors and cell types including neurons. In this report, TRAIL protein levels were increased in human monocyte-derived macrophages (MDM) after HIV-1 infection and immune activation. In HIV-1 encephalitic (HIVE) human brain tissue, TRAIL-expressing macrophages were found in association with active caspase-3 positive neurons. Cytotoxic TRAIL receptors 1 and 2 were expressed on neurons in primary human fetal cultures and HIV-1 encephalitic brain tissue. Furthermore, TRAIL induced a dose-dependent effect on neuronal apoptosis. These results support a role for TRAIL in mononuclear phagocyte (MP)-mediated neurotoxicity in HIV-1-associated dementia (HAD).
Предметные рубрики MeSH
AIDS Dementia ComplexAcquired Immunodeficiency SyndromeAdultAntibodies, MonoclonalApoptosisApoptosis Regulatory ProteinsCaspasesCell CountCells, CulturedEmbryo, MammalianEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryHIV Core Protein p24HumansImmunohistochemistryIn Situ Nick-End LabelingLipopolysaccharidesMaleMembrane GlycoproteinsMicrotubule-Associated ProteinsMiddle AgedMonocytesNeuronsReceptors, TNF-Related Apoptosis-Inducing LigandReceptors, Tumor Necrosis FactorTNF-Related Apoptosis-Inducing LigandTumor Necrosis Factor-alphaZidovudine