Revista da Sociedade Brasileira de Medicina Tropical · 2016
There is no evident correlation between interleukin-10 gene polymorphisms and periportal fibrosis regression after specific treatment.
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Silva Paula Carolina Valença, Silva Aline Vieira da, Silva Taysa Nascimento, Vasconcelos Letícia Moura de, Gomes Adriana Vieira, Coêlho Maria Rosângela Cunha Duarte, Muniz Maria Tereza Cartaxo, Domingues Ana Lúcia Coutinho
Аннотация
INTRODUCTION:: We evaluated the associations between interleukin-10 (IL-10) gene polymorphisms -G1082A/-C819T/-C592A and periportal fibrosis regression after specific treatment for schistosomiasis.
METHODS:: This retrospective cohort study involved 125 Brazilian patients infected with Schistosomiasis mansoni, who were followed up for 2 years after specific treatment to estimate the probability of periportal fibrosis regression.
RESULTS:: There was no evidence of associations between IL-10 polymorphisms and periportal fibrosis regression after treatment.
CONCLUSIONS:: There was no evidence of associations between gene promoter polymorphisms of IL-10 and the regression of periportal fibrosis in this Brazilian population.
METHODS:: This retrospective cohort study involved 125 Brazilian patients infected with Schistosomiasis mansoni, who were followed up for 2 years after specific treatment to estimate the probability of periportal fibrosis regression.
RESULTS:: There was no evidence of associations between IL-10 polymorphisms and periportal fibrosis regression after treatment.
CONCLUSIONS:: There was no evidence of associations between gene promoter polymorphisms of IL-10 and the regression of periportal fibrosis in this Brazilian population.