Long-Term Exposure to Transportation Noise and Ischemic Heart Disease: A Pooled Analysis of Nine Scandinavian Cohorts.
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Pyko Andrei, Roswall Nina, Ögren Mikael, Oudin Anna, Rosengren Annika, Eriksson Charlotta, Segersson David, Rizzuto Debora, Andersson Eva M, Aasvang Gunn Marit, Engström Gunnar, Gudjonsdottir Hrafnhildur, Jørgensen Jeanette T, Selander Jenny, Christensen Jesper H, Brandt Jørgen, Leander Karin, Overvad Kim, Eneroth Kristina, Mattisson Kristoffer, Barregard Lars, Stockfelt Leo, Albin Maria, Simonsen Mette K, Tiittanen Pekka, Molnar Peter, Ljungman Petter, Solvang Jensen Steen, Gustafsson Susanna, Lanki Timo, Lim Youn-Hee, Andersen Zorana J, Sørensen Mette, Pershagen Göran
Аннотация
OBJECTIVES: The study aimed to assess exposure-response relationships for different transportation noise sources and ischemic heart disease (IHD), including subtypes.
METHODS: Pooled analyses were performed of nine cohorts from Denmark and Sweden, together including 132,801 subjects. Time-weighted long-term exposure to road, railway, and aircraft noise, as well as air pollution, was estimated based on residential histories. Hazard ratios (HRs) were calculated using Cox proportional hazards models following adjustment for lifestyle and socioeconomic risk factors.
RESULTS: A total of 22,459 incident cases of IHD were identified during follow-up from national patient and mortality registers, including 7,682 cases of myocardial infarction. The adjusted HR for IHD was 1.03 [95% confidence interval (CI) 1.00, 1.05] per 10 dB Lden for both road and railway noise exposure during 5 y prior to the event. Higher risks were indicated for IHD excluding angina pectoris cases, with HRs of 1.06 (95% CI: 1.03, 1.08) and 1.05 (95% CI: 1.01, 1.08) per 10 dB Lden for road and railway noise, respectively. Corresponding HRs for myocardial infarction were 1.02 (95% CI: 0.99, 1.05) and 1.04 (95% CI: 0.99, 1.08). Increased risks were observed for aircraft noise but without clear exposure-response relations. A threshold at around 55 dB Lden was suggested in the exposure-response relation for road traffic noise and IHD.
DISCUSSION: Exposure to road, railway, and aircraft noise in the prior 5 y was associated with an increased risk of IHD, particularly after exclusion of angina pectoris cases, which are less well identified in the registries. https://doi.org/10.1289/EHP10745.