Transactions of the Royal Society of Tropical Medicine and Hygiene · 2022
The observed relationship between the degree of parasite aggregation and the prevalence of infection within human host populations for soil-transmitted helminth and schistosome infections.
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Kura Klodeta, Truscott James E, Collyer Benjamin S, Phillips Anna, Garba Amadou, Anderson Roy M
Аннотация
BACKGROUND: Soil-transmitted helminths (STH) and schistosome parasites are highly aggregated within the human population. The probability distribution of worms per person is described well by the negative binomial probability distribution with aggregation parameter, k, which varies inversely with parasite clustering. The relationship between k and prevalence in defined populations subject to mass drug administration is not well understood.
METHODS AND RESULTS: We use statistical methods to estimate k using two large independent datasets for STH and schistosome infections from India and Niger, respectively, both of which demonstrate increased aggregation of parasites in a few hosts, as the prevalence of infections declines across the dataset.
CONCLUSIONS: A greater attention needs to be given in monitoring and evaluation programmes to find and treat the remaining aggregates of parasites.
METHODS AND RESULTS: We use statistical methods to estimate k using two large independent datasets for STH and schistosome infections from India and Niger, respectively, both of which demonstrate increased aggregation of parasites in a few hosts, as the prevalence of infections declines across the dataset.
CONCLUSIONS: A greater attention needs to be given in monitoring and evaluation programmes to find and treat the remaining aggregates of parasites.