Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
Neuropsychological test performance in mild cognitive impairment with Lewy bodies: A systematic review and meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод пока не подготовлен
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Wyman-Chick Kathryn A, Bayram Ece, Gravett Stephanie, D'Antonio Fabrizia, Rodriguez-Porcel Federico, Kane Joseph P M, Ferman Tanis J, Olson-Bullis Barbara A, Boeve Bradley F, Bonanni Laura, Ferreira Daniel, Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Lewy Body Dementias Professional Interest Area (LBD PIA) Prodromal Working Group
Аннотация
BACKGROUND: We sought to characterize the cognitive profile among individuals with mild cognitive impairment with Lewy bodies (MCI-LB) to help guide future clinical criteria.
METHODS: Systematic review and meta-analysis included MCI-LB studies with cognitive data from PubMed, Embase, Web of Science, and PsycINFO (January 1990 to March 2023). MCI-LB scores were compared to controls, MCI due to Alzheimer's disease (MCI-AD), and dementia with Lewy bodies (DLB) groups with random-effects models.
RESULTS: We included 26 studies and 2823 participants. Across all domains, the MCI-LB group performed worse than controls and better than DLB. Compared to MCI-AD, the MCI-LB group performed worse in attention/processing speed (g = -0.24, 95% confidence interval [CI]: -0.35, -0.12), attention/executive (g = -0.42, 95% CI: -0.56, -0.28); better in verbal immediate recall (g = 0.37; 95% CI: 0.15, 0.59) and delayed memory (g = 0.40; 95% CI: 0.22, 0.58).
DISCUSSION: The cognitive profiles in MCI-LB and MCI-AD are consistent with established profiles in DLB and AD. Neuropsychological assessment may be helpful in differential diagnosis, even in early disease states.
HIGHLIGHTS: We performed a systematic review and meta-analysis for cognition in mild cognitive impairment with Lewy bodies (MCI-LB). Compared to MCI due to Alzheimer's disease (MCI-AD), MCI-LB had worse attention, executive function, and processing speed. Compared to MCI-AD, MCI-LB had better verbal immediate and delayed recall. The MCI-LB group was worse on all cognitive domains than controls, and better than dementia with Lewy bodies. Studies used different tests and there is a need for global efforts for harmonization.
METHODS: Systematic review and meta-analysis included MCI-LB studies with cognitive data from PubMed, Embase, Web of Science, and PsycINFO (January 1990 to March 2023). MCI-LB scores were compared to controls, MCI due to Alzheimer's disease (MCI-AD), and dementia with Lewy bodies (DLB) groups with random-effects models.
RESULTS: We included 26 studies and 2823 participants. Across all domains, the MCI-LB group performed worse than controls and better than DLB. Compared to MCI-AD, the MCI-LB group performed worse in attention/processing speed (g = -0.24, 95% confidence interval [CI]: -0.35, -0.12), attention/executive (g = -0.42, 95% CI: -0.56, -0.28); better in verbal immediate recall (g = 0.37; 95% CI: 0.15, 0.59) and delayed memory (g = 0.40; 95% CI: 0.22, 0.58).
DISCUSSION: The cognitive profiles in MCI-LB and MCI-AD are consistent with established profiles in DLB and AD. Neuropsychological assessment may be helpful in differential diagnosis, even in early disease states.
HIGHLIGHTS: We performed a systematic review and meta-analysis for cognition in mild cognitive impairment with Lewy bodies (MCI-LB). Compared to MCI due to Alzheimer's disease (MCI-AD), MCI-LB had worse attention, executive function, and processing speed. Compared to MCI-AD, MCI-LB had better verbal immediate and delayed recall. The MCI-LB group was worse on all cognitive domains than controls, and better than dementia with Lewy bodies. Studies used different tests and there is a need for global efforts for harmonization.