Indoles as promising Therapeutics: A review of recent drug discovery efforts.

Indole, a fundamental heterocyclic core, has emerged as a cornerstone in the medicinal chemistry due to its diverse biological activities and structural versatility. This aromatic compound, present in natural as well as synthetic compounds, offers a versatile platform for the drug discovery. By strategically incorporating functional groups or pharmacophores, researchers can tailor indole-derivatives to target a wide range of diseases. This review delves into the multifaceted applications of indole derivatives, highlighting their potential as therapeutic agents for cancer, diabetes, depression, Alzheimer's diseases, Parkinson's disease, etc. emphasizing how indole derivatives can enhance potency and selectivity. By understanding the structure-activity relationship of indole compounds, scientists can develop innovative drug candidates with improved therapeutic profiles. The review highlights the diverse nature of indole-based derivatives along with the structure-activity relationshipThe current review comprehensively covers the advancements and developments in the field over the past seven years, specifically from 2017 to 2024. This timeframe was selected to provide an up-to-date and thorough analysis of recent progress, capturing significant trends, breakthroughs, and emerging insights within the domain. By focusing on this period, the review ensures relevance and highlights the evolving landscape of research, offering a detailed synthesis of key findings and their implications for future studies.