The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2012
CD226 Gly307Ser association with neuromyelitis optica in Southern Han Chinese.
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Liu Chao, Wang Guansan, Liu Hong, Li Yue, Li Jin, Dai Yongqiang, Hu Xueqiang
Аннотация
BACKGROUND: Neuromyelitis optica (NMO) and multiple sclerosis (MS) are autoimmune diseases of the central nervous system with complex pathogeneses. NMO was once considered to be a severe variant of MS. There has been more evidence that a non-synonymous exchange (rs763361/Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including multiple sclerosis (MS). However, no studies have investigated the role of rs763361 in the pathogenesis of NMO.
OBJECTIVES: The goal of our study is to evaluate the role of CD226 Gly307Ser in neuromyelitis optica (NMO) in Southern Han Chinese.
METHODS: Eight-nine NMO patients, 93 relapsing-remitting multiple sclerosis (RRMS) patients, and 122 controls (CTLs) were enrolled. The rs763361 alleles of the subjects were determined by sequencing-based typing.
RESULTS: The results strongly support that the TT genotypes are associated with NMO but are not significantly correlated with susceptibility for MS.
CONCLUSIONS: CD226 Gly307Ser may correlate with risk of NMO in Southern Han Chinese.
OBJECTIVES: The goal of our study is to evaluate the role of CD226 Gly307Ser in neuromyelitis optica (NMO) in Southern Han Chinese.
METHODS: Eight-nine NMO patients, 93 relapsing-remitting multiple sclerosis (RRMS) patients, and 122 controls (CTLs) were enrolled. The rs763361 alleles of the subjects were determined by sequencing-based typing.
RESULTS: The results strongly support that the TT genotypes are associated with NMO but are not significantly correlated with susceptibility for MS.
CONCLUSIONS: CD226 Gly307Ser may correlate with risk of NMO in Southern Han Chinese.
Предметные рубрики MeSH
AdultAge of OnsetAntigens, Differentiation, T-LymphocyteAsian PeopleCase-Control StudiesChinaConfidence IntervalsFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeGlycineHumansMaleNeuromyelitis OpticaOdds RatioSerineYoung AdultT Lineage-Specific Activation Antigen 1