[Type 2 innate lymphoid cells and chronic rhinosinusitis].

Type 2 innate lymphoid cells (ILC2) is a new group of the innate lymphoid cells which has been recently discovered. These cells can produce type 2 cytokines such as interleukin-5 (IL-5) and interleukin-13 (IL-13) on response to interleukin-33 (IL-33), interleukin-25(IL-25) and thymic stromal lymphopoietin (TSLP) to initiate and maintain the type 2 inflammation in human. Nasal polyps from patients with chronic rhinosinusitis (CRS) show enrichment for ILC2, which suggests ILC2 could have a critical role in the occurrence/development of nasal polyps. This review focuses on discovery of ILC2, immunological properties of ILC2 and ILC2 in CRS.