Hidradenitis Suppurativa in a Large Cohort of Italian Patients: Evaluation of the Burden of Disease.
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Fabbrocini Gabriella, Ruina Giulia, Giovanardi Giulia, Dini Valentina, Raone Beatrice, Venturini Marina, Caposiena Caro Raffaele Dante, Veraldi Stefano, Cannavò Serafinella Patrizia, Merlo Giulia, Bertoldi Alberto Maria, Fiorentini Federica, Molinelli Elisa, Atzori Laura, Bongiorno Maria Rita, Lo Re Michele, Skroza Nevena, Lasagni Claudia, Franchi Chiara, Ardigò Marco, Di Costanzo Luisa, Stingeni Luca, Amerio Paolo, Sanna Federica, Pescitelli Leonardo, Broganelli Paolo, De Cupis Claudia, Gualberti Giuliana, Saragaglia Valeria, Argenziano Giuseppe
Аннотация
OBJECTIVE: To evaluate how the burden of HS disease impacts on patient well-being and working activities in a large Italian population over a period of 9 months.
METHODS: A multicenter, prospective, epidemiologic cohort study was conducted in adult Italian patients with HS. HS severity was assessed through Hurley stage and HS Physician's Global Assessment (HS-PGA), clinical improvement by HS Clinical Response (HiSCR) and partial response, and disease burden through QoL questionnaires (HIDRAdisk, Skindex-16, Dermatology Life Quality Index [DLQI]), and Work Productivity and Activity Impairment - General Health (WPAI:GH).
RESULTS: A total of 308 patients (56.2% women; mean age 35.2 ± 12.9 years) were enrolled in 27 dermatologic clinics. Men were older (37.4 years vs. 33.5), more smoking addicted (74.1% vs. 60.1%), and alcohol consumer (34.1% vs. 13.9%), while more women were obese (34.10% vs. 22.22%). At baseline, most patients had a Hurley severity stage of 2 (43.9%), a moderate HS-PGA score (57.1%), and poor QoL (HIDRAdisk: 65.7 ± 23.3, Skindex-16: 60.3 ± 26.9, and DLQI: 10.8 ± 8.1). Patients with more severe disease showed worse QoL. Mean values for the variables related to HS severity decreased during the study period. The achievement of HiSCR and partial response increased during the study.
CONCLUSION: This study offers insight into the disease burden of HS in an Italian population. Our results underline the impact of QoL evaluation, also with the use of the HIDRAdisk, in clinical routine as a support to validated severity clinical and instrumental indexes for a "360-degree" assessment of HS patient's burden of disease.