The Journal of dermatological treatment · 2022
Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis.
СтатьяМетаанализСистематический обзорНазвание и аннотация: Перевод пока не подготовлен
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Froehlich Michael H, Conti Keith R, Norris Ivy I, Allensworth Jordan J, Ufkes Nicole A, Nguyen Shaun A, Bruner Evelyn T, Cook Joel, Day Terry A
Аннотация
BACKGROUND: Endocrine mucin-producing sweat gland carcinoma is a rare, under-reported cutaneous adnexal tumor that is often misdiagnosed and has an unknown incidence of metastasis.
OBJECTIVE: To determine the incidence of metastasis and tumor recurrence, as well as diagnostic accuracy and current trends in treatment modality.
METHODS: A search was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Tumor pathology and clinical data concerning demographics, presentation, diagnosis, treatment and follow-up were assessed.
RESULTS: A total of 36 publications with 110 cases were identified. Initial pathological diagnosis was incorrect in 45.5% of cases. One case of metastatic disease was reported. The incidence of locoregional recurrence was 10.6% over a mean follow-up period of 21.3 months. Of cases with known methods of resection, 34.6% were resected by excisional biopsy, 42.8% were resected by wide surgical excision, and 31.3% were cleared by Mohs micrographic surgery.
LIMITATIONS: The low reported incidence and level of evidence was suboptimal with only case reports and retrospective case studies being reported.
CONCLUSION: Reported cases of this pathology demonstrate poor diagnostic accuracy. High rates of misdiagnosis and inadequate definitive treatment suggest the need for more comprehensive work-up and management of lesions suspicious for this pathology.
OBJECTIVE: To determine the incidence of metastasis and tumor recurrence, as well as diagnostic accuracy and current trends in treatment modality.
METHODS: A search was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Tumor pathology and clinical data concerning demographics, presentation, diagnosis, treatment and follow-up were assessed.
RESULTS: A total of 36 publications with 110 cases were identified. Initial pathological diagnosis was incorrect in 45.5% of cases. One case of metastatic disease was reported. The incidence of locoregional recurrence was 10.6% over a mean follow-up period of 21.3 months. Of cases with known methods of resection, 34.6% were resected by excisional biopsy, 42.8% were resected by wide surgical excision, and 31.3% were cleared by Mohs micrographic surgery.
LIMITATIONS: The low reported incidence and level of evidence was suboptimal with only case reports and retrospective case studies being reported.
CONCLUSION: Reported cases of this pathology demonstrate poor diagnostic accuracy. High rates of misdiagnosis and inadequate definitive treatment suggest the need for more comprehensive work-up and management of lesions suspicious for this pathology.