The Journal of infectious diseases · 2024
Vertical Transmission of SARS-CoV-2-Specific Antibodies and Cytokine Profiles in Pregnancy.
СтатьяПоддержка исследования: вне правительства СШАПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Monroe Jonathon M, Quach Huy Quang, Punia Sohan, Enninga Elizabeth Ann L, Fedyshyn Yaroslav, Girsch James H, Fedyshyn Bohdana, Lemens Maureen, Littlefield Dawn, Behl Supriya, Sintim-Aboagye Elise, Mejia Plazas Maria C, Yamaoka Satoko, Ebihara Hideki, Pandey Akhilesh, Correia Cristina, Ung Choong Yong, Li Hu, Vassallo Robert, Sun Jie, Johnson Erica L, Olson Janet E, Theel Elitza S, Badley Andrew D, Kennedy Richard B, Theiler Regan N, Chakraborty Rana
Аннотация
Despite intensive characterization of immune responses after COVID-19 infection and vaccination, research examining protective correlates of vertical transmission in pregnancy are limited. Herein, we profiled humoral and cellular characteristics in pregnant women infected or vaccinated at different trimesters and in their corresponding newborns. We noted a significant correlation between spike S1-specific IgG antibody and its RBD-ACE2 blocking activity (receptor-binding domain-human angiotensin-converting enzyme 2) in maternal and cord plasma (P < .001, R > 0.90). Blocking activity of spike S1-specific IgG was significantly higher in pregnant women infected during the third trimester than the first and second trimesters. Elevated levels of 28 cytokines/chemokines, mainly proinflammatory, were noted in maternal plasma with infection at delivery, while cord plasma with maternal infection 2 weeks before delivery exhibited the emergence of anti-inflammatory cytokines. Our data support vertical transmission of protective SARS-CoV-2-specific antibodies. This vertical antibody transmission and the presence of anti-inflammatory cytokines in cord blood may offset adverse outcomes of inflammation in exposed newborns.