Protection from physical noxae.

Protection from physical noxae must include multiple approaches; physical irritant contact dermatitis develops most likely when the cumulative exposure to several physical factors, such as climatic environmental conditions and friction, pressure or occlusion is given. The additive effect of these conditions, frequently found in modern working environments, not only provokes barrier disturbances, but also inflammatory reactions of the deeper layers of the skin. This review reflects on some examples of occupational physical irritant contact dermatitis (PICD) and the current understanding of its possible pathomechanism. On the one hand, the literature reveals epidemiological studies and case reports and on the other hand murine studies. The combination of both views may permit new insights into the pathogenic mechanisms of PICD and its prevention.