Biogenesis of hepatic acute-phase response to trauma.

The bioorganic pathway(s) of hepatic acute-phase response in rat to single and compounded traumata triggered either by chemical or physical injury has been re-evaluated for the purpose of advancing a better understanding of mechanisms of hepatic regeneration. These insights would be useful in cases of liver cirrhosis and end-stage liver diseases and may allow avenues of surgical management other than liver transplantation. Mechanisms of acute-phase response in rat to a single inflammatory stimulus, e.g. intoxication with phalloidin, alpha-amanitin, subcutaneous administration of carageenan, subcutaneous implantation of Yoshida sarcoma or i.p. administration of Zajdela ascites are discussed and compared with (a) acute-phase response to intoxication by various factors leading to the development of liver cirrhosis, and (b) acute-phase response of nascent hepatocytes where hepatic regenerative activities were induced by chemical intoxication or surgical partial hepatectomy. Interestingly, hepatic acute-phase response was not limited only to these injuries outlined above but also to psychological conditions.