Geriatrics & gerontology international · 2025
Pre-Operative Resistance Training and Amino Acid Supplementation in Frail Patients With Gastrointestinal Cancer: A Randomized Clinical Trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Fujimoto Taku, Akasaka Hiroshi, Yasunobe Yukiko, Yoshida Shino, Onishi Yuri, Minami Tomohiro, Terashima Ken, Shirai Mari, Isaka Masaaki, Tanaka Minoru, Sugimoto Ken, Koriyama Hiroshi, Takami Yoichi, Yamasaki Makoto, Yamashita Kotaro, Noda Takehiro, Takahashi Hidekazu, Eguchi Hidetoshi, Doki Yuichiro, Rakugi Hiromi, Yamamoto Koichi
Аннотация
AIM: To investigate the impact of preoperative exercise and nutritional interventions on postoperative complications, physical function, and activities of daily living (ADL) 1 year postoperatively in frail older patients with gastrointestinal cancer.
METHODS: This single-center, randomized controlled trial enrolled 62 patients aged ≥ 70 years scheduled to undergo elective surgery for gastrointestinal cancer with decreased grip strength or walking speed between October 2017 and December 2022. Participants were randomly assigned to control (n = 33) and intervention (n = 29) groups; the latter performed resistance exercises and consumed amino acid-containing jelly daily at home for 14 days. All participants were followed-up for 1 year.
RESULTS: After exclusion, 27 and 18 patients were enrolled in the control and intervention groups, respectively. The average age was 80.4 years, and 37.8% were male. Postoperative complications were observed in 51.9% and 44.4% of the control and intervention groups, respectively (95% confidence interval [CI] 0.62-2.19), with postoperative delirium observed in 25.9% and 33.3%, respectively (95% CI 0.31-1.94). There were no significant inter-group differences in grip strength, walking speed, or skeletal muscle index. However, the intervention group showed superior knee extension strength maintenance (preoperatively: 100.2% ± 18.3% vs. 119.1% ± 68.8%, p = 0.19; discharge: 86.7% ± 22.0% vs. 119.3% ± 72.0%, p = 0.044), and lower rates of decreased ADLs or death 1 year postoperatively (42.3% vs. 23.5%; RR 0.56, 95% CI 0.08-1.92).
CONCLUSIONS: This 14-day preoperative exercise and nutritional intervention program did not significantly reduce postoperative complications in frail older patients with gastrointestinal cancer; however, it aided in maintaining knee extension strength at discharge.
METHODS: This single-center, randomized controlled trial enrolled 62 patients aged ≥ 70 years scheduled to undergo elective surgery for gastrointestinal cancer with decreased grip strength or walking speed between October 2017 and December 2022. Participants were randomly assigned to control (n = 33) and intervention (n = 29) groups; the latter performed resistance exercises and consumed amino acid-containing jelly daily at home for 14 days. All participants were followed-up for 1 year.
RESULTS: After exclusion, 27 and 18 patients were enrolled in the control and intervention groups, respectively. The average age was 80.4 years, and 37.8% were male. Postoperative complications were observed in 51.9% and 44.4% of the control and intervention groups, respectively (95% confidence interval [CI] 0.62-2.19), with postoperative delirium observed in 25.9% and 33.3%, respectively (95% CI 0.31-1.94). There were no significant inter-group differences in grip strength, walking speed, or skeletal muscle index. However, the intervention group showed superior knee extension strength maintenance (preoperatively: 100.2% ± 18.3% vs. 119.1% ± 68.8%, p = 0.19; discharge: 86.7% ± 22.0% vs. 119.3% ± 72.0%, p = 0.044), and lower rates of decreased ADLs or death 1 year postoperatively (42.3% vs. 23.5%; RR 0.56, 95% CI 0.08-1.92).
CONCLUSIONS: This 14-day preoperative exercise and nutritional intervention program did not significantly reduce postoperative complications in frail older patients with gastrointestinal cancer; however, it aided in maintaining knee extension strength at discharge.