Leukemia & lymphoma · 2018
Granulocyte colony-stimulating factor and respiratory status of critically ill neutropenic patients with hematologic malignancies.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Mignard Xavier, Biard Lucie, Lemiale Virginie, Mokart Djamel, Pène Frédéric, Kouatchet Achille, Mayaux Julien, Vincent François, Nyunga Martine, Bruneel Fabrice, Rabbat Antoine, Lebert Christine, Perez Pierre, Meert Anne-Pascale, Benoit Dominique, Hamidfar Rebecca, Darmon Michael, Azoulay Elie, Zafrani Lara
Аннотация
In patients with hematologic malignancies, respiratory status may deteriorate during neutropenia recovery. This multicenter, observational study aims to evaluate granulocyte colony-stimulating factor (G-CSF) impact on respiratory status in critically ill neutropenic patients. Among 1011 critically ill patients with hematologic malignancies, 288 were neutropenic and included in this study. 201 (70%) did not receive G-CSF at day 1 or 2. After propensity score matching for the probability of receiving G-CSF at day 1 or 2, there was no association between G-CSF and respiratory deterioration at day 14 (OR =1.19; 95%CI (0.57-2.51); p = .64). Additional sensitivity analysis in patients admitted for acute respiratory failure showed similar results (OR =1.34; 95%CI (0.5-3.59); p = .57). Among patients who recovered from neutropenia, 75% experienced respiratory deterioration during neutropenia recovery. This study confirms that neutropenia recovery is a situation at risk of respiratory deterioration. However, whether G-CSF is an aggravating factor cannot be supported by our results.