Unveiling the revolutionary approach for psoriasis management: Leveraging the breakthrough capabilities of hyaluronic acid.

Psoriasis is an unexceptional autoimmune-mediated, inflammatory skin disorder impacting systemic skin functions. The pathophysiology of psoriasis comprises hyperproliferation of cells on the epidermis, differentiation of keratinocytes, and the impaired barrier function of the epidermal layer of the skin, developing in the thickening of the epidermal layer. From a range of inflammatory mediators concerned during the pathogenesis of psoriasis, IL-17, -23, and TNF-α exert a significant influence on the upregulation of the symptoms. There are diverse conventional approaches dealing with psoriasis, including topical, systemic, biological, and herbal formulations. The demand for innovative formulations has emerged as several adverse effects correspond to conventionally pre-existing formulations. As hyaluronic acid (HA) has manifold structural and functional characteristics that can be worthwhile in regulating the symptoms of multiple skin inflammatory conditions, it can be used in novel formulations to amplify therapeutic effectiveness and achieve enviable responses. Moreover, HA can also serve the role of a biomarker for psoriasis according to its molecular weight. Furthermore, the mechanistic role of HA in its native form can be advantageous in ameliorating the symptoms of psoriasis. This review unequivocally covers fundamental aspects and the latest advancements in HA-based formulations for mitigating psoriasis symptoms. Furthermore, we deliberated on the role of HA as a biomarker in the physiological system of humans, in accordance with its molecular weight, the rationale behind its selection, and its mechanistic role, and how HA profoundly augments the impactfulness of various formulations in eliciting a prominent therapeutic improvement and mitigating symptoms associated with this disease.