Journal of pharmaceutical and biomedical analysis · 2021
Identification of Novel Impurity of Ziprasidone.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Murkute Sunil R, Singh Girij P, Vasantharaju S G, Bhat Krishnamurthy, Godbole Himanshu M, Upadhyay Pritesh R, Trivedi Anurag
Аннотация
Ziprasidone hydrochloride is a second-generation antipsychotic drug employed for the treatment of schizophrenia and acute mania or mixed episodes associated with bipolar disorder. During the scale-up of ziprasidone hydrochloride, an unknown impurity was observed in the batches ranging from 0.10% to 0.15% by HPLC-UV analysis. The structure of an unknown impurity was proposed as 3,3'-methylenebis(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one) which is named as methylene ziprasidone dimer (MZD impurity). It was isolated from an enriched sample by preparative HPLC, and its structure was elucidated by comprehensive analysis of HRMS, 1D NMR (1H, 13C), DEPT-135, 2D NMR (COSY, HSQC, HMBC) spectroscopy. A plausible mechanism for the formation of isolated impurity is proposed.