Cancer control : journal of the Moffitt Cancer Center · 2020
Targeting BRAF-Mutant Biliary Tract Cancer: Recent Advances and Future Challenges.
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Rizzo Alessandro, Federico Alessandro Di, Ricci Angela Dalia, Frega Giorgio, Palloni Andrea, Pagani Rachele, Tavolari Simona, Marco Mariacristina Di, Brandi Giovanni
Аннотация
BACKGROUND: Biliary tract cancers (BTCs) represent a heterogeneous group of aggressive solid tumors with limited therapeutic options, and include gallbladder cancer (GBC), ampulla of Vater cancer (AVC), intrahepatic cholangiocarcinoma (iCCA) and extrahepatic cholangiocarcinoma (eCCA).
METHODS & RESULTS: In the current review, we will discuss recent results of clinical trials testing targeted therapies in BRAF-mutant BTCs, with a particular focus on the recently published Phase II ROAR trial and ongoing active and recruiting clinical trials.
CONCLUSIONS: Although the extended use of molecular profiling has paved the way toward a new era in BTC management, targeted therapies are limited to iCCA so far, and the prognosis of patients with metastatic disease has substantially not changed in the last decade. In this discouraging scenario, BRAF inhibition is currently emerging as a novel treatment option in patients harboring BRAF mutations.
METHODS & RESULTS: In the current review, we will discuss recent results of clinical trials testing targeted therapies in BRAF-mutant BTCs, with a particular focus on the recently published Phase II ROAR trial and ongoing active and recruiting clinical trials.
CONCLUSIONS: Although the extended use of molecular profiling has paved the way toward a new era in BTC management, targeted therapies are limited to iCCA so far, and the prognosis of patients with metastatic disease has substantially not changed in the last decade. In this discouraging scenario, BRAF inhibition is currently emerging as a novel treatment option in patients harboring BRAF mutations.
Предметные рубрики MeSH
Ampulla of VaterAntineoplastic Combined Chemotherapy ProtocolsBile DuctsBiliary Tract NeoplasmsCholangiocarcinomaGallbladderHumansMolecular Targeted TherapyMutationNeoplasm StagingObservational Studies as TopicPrognosisProgression-Free SurvivalProtein Kinase InhibitorsProto-Oncogene Proteins B-rafRandomized Controlled Trials as Topic