Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
Consumption of plant sterols-enriched soy milk with a healthy dietary pattern diet lowers blood pressure in adults with metabolic syndrome: A randomized controlled trial.
СтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Xu Yujing, Sutanto Clarinda Nataria, Xia Xuejuan, Toh Darel Wee Kiat, Gan Alicia Xinli, Deng Qiyun, Ling Lieng Hsi, Khoo Chin Meng, Foo Roger Sik-Yin, Kim Jung Eun
Аннотация
BACKGROUND & AIMS: Plant sterols (PS) have been shown to lower blood lipid-lipoproteins concentrations and may serve as a potential functional ingredient for cardiovascular disease (CVD) risk management. However, there are limited studies examining this effect in individuals with metabolic syndrome (MetS). The aim of this study was to evaluate the effects of PS-enriched food consumption as part of a healthy dietary pattern (HDP) on blood pressure and endothelial function in Singaporean adults with MetS.
METHODS AND RESULTS: This was a 12-week, crossover, randomized controlled trial with a 4-week washout period. Thirteen subjects were instructed to consume an HDP diet either with normal soy milk (control group) or with PS (2 g/day)-enriched soy milk (PS group) for 4 weeks. Blood lipid-lipoproteins and glucose concentrations, blood pressure, and endothelial function-related indicators (flow-mediated dilation, total plasma nitrate/nitrite and endothelin-1, circulating endothelial progenitor cells) were assessed before and after the intervention. Systolic blood pressure [mean change, PS group: -4.0 ± 3.7 mmHg; control group: 5.9 ± 2.5 mmHg (PInteraction = 0.01)] and long-term CVD risk [mean change, PS group: -0.2 ± 1.0 %; control group: 2.7 ± 1.3 % (PInteraction = 0.03)] decreased following PS consumption. No changes were observed in the other endothelial function-related outcomes.
CONCLUSIONS: Consumption of PS-enriched food with an HDP diet may lower blood pressure and long-term CVD risk in adults with MetS.
CLINICAL TRIAL REGISTRATION: NCT03723330, https://clinicaltrials.gov/.
METHODS AND RESULTS: This was a 12-week, crossover, randomized controlled trial with a 4-week washout period. Thirteen subjects were instructed to consume an HDP diet either with normal soy milk (control group) or with PS (2 g/day)-enriched soy milk (PS group) for 4 weeks. Blood lipid-lipoproteins and glucose concentrations, blood pressure, and endothelial function-related indicators (flow-mediated dilation, total plasma nitrate/nitrite and endothelin-1, circulating endothelial progenitor cells) were assessed before and after the intervention. Systolic blood pressure [mean change, PS group: -4.0 ± 3.7 mmHg; control group: 5.9 ± 2.5 mmHg (PInteraction = 0.01)] and long-term CVD risk [mean change, PS group: -0.2 ± 1.0 %; control group: 2.7 ± 1.3 % (PInteraction = 0.03)] decreased following PS consumption. No changes were observed in the other endothelial function-related outcomes.
CONCLUSIONS: Consumption of PS-enriched food with an HDP diet may lower blood pressure and long-term CVD risk in adults with MetS.
CLINICAL TRIAL REGISTRATION: NCT03723330, https://clinicaltrials.gov/.