International ophthalmology · 2020
Venous blood flow alterations in glaucoma patients.
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Orgül Selim, Gugleta Konstantin, Grieshaber Matthias C, Schoetzau Andreas
Аннотация
PURPOSE: To evaluate the correlation between retinal venous blood flow parameters and glaucomatous visual field damage in a retrospective analysis.
METHODS: Fifty-five (24 male, 31 female) glaucoma patients, under intraocular pressure (IOP) reducing treatment, aged (mean ± SD) 69 ± 10 years, 29 with primary open-angle and 26 with normal-tension glaucoma, were evaluated with regard to the correlation between IOP, color Doppler retinal venous blood flow velocity and glaucomatous damage.
RESULTS: Univariate regression analysis disclosed statistically significant correlations of the visual field index MD with age, IOP and venous blood flow (p ≤ 0.026 for each parameter). A mixed linear effects model disclosed a significant correlation of MD with age, IOP and venous blood flow (p ≤ 0.002 for each parameter), but not with sex, side (right eye versus left eye) and diagnosis (primary open-angle glaucoma versus normal-tension glaucoma). Finally, interocular difference (right eye vs. left eye of the same patient) in MD correlated with interocular differences in venous blood flow velocities (p < 0.001), but not with interocular differences in IOP.
CONCLUSIONS: Glaucomatous damage correlated negatively with retinal venous blood flow velocity, be it between subjects or between eyes within individuals. This study is limited by its cross-sectional design, and it is not possible to draw any conclusion with regard to the origin of the correlations.
METHODS: Fifty-five (24 male, 31 female) glaucoma patients, under intraocular pressure (IOP) reducing treatment, aged (mean ± SD) 69 ± 10 years, 29 with primary open-angle and 26 with normal-tension glaucoma, were evaluated with regard to the correlation between IOP, color Doppler retinal venous blood flow velocity and glaucomatous damage.
RESULTS: Univariate regression analysis disclosed statistically significant correlations of the visual field index MD with age, IOP and venous blood flow (p ≤ 0.026 for each parameter). A mixed linear effects model disclosed a significant correlation of MD with age, IOP and venous blood flow (p ≤ 0.002 for each parameter), but not with sex, side (right eye versus left eye) and diagnosis (primary open-angle glaucoma versus normal-tension glaucoma). Finally, interocular difference (right eye vs. left eye of the same patient) in MD correlated with interocular differences in venous blood flow velocities (p < 0.001), but not with interocular differences in IOP.
CONCLUSIONS: Glaucomatous damage correlated negatively with retinal venous blood flow velocity, be it between subjects or between eyes within individuals. This study is limited by its cross-sectional design, and it is not possible to draw any conclusion with regard to the origin of the correlations.